中国血液净化

›› 2003, Vol. 2 ›› Issue (9): 472-475.

• 论著 • 上一篇    下一篇

终末期肾病血液透析患者动脉弹性功能的研究

刁晓艳 孙宁玲 张 凌 谌贻璞   

  1. 100044 北京，北京大学人民医院心内科［刁晓艳(现在贵阳医学院附属医院工作)，孙宁玲］；100029 北京，中日友好医院透析中心（张凌），肾内科（谌贻璞）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-09-19 发布日期:2003-09-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-09-19 Published:2003-09-19

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摘要：

目的 探讨终末期肾病(ESRD)血液透析患者动脉弹性功能的特点。方法 采用 Dynapulse 200M动 脉功能测定仪检测172例ESRD长期维持透析患者透析前血压及动脉弹性功能。结果 与正常标准比血液透析患者的系统血管顺应性（SVC）、肱动脉顺应性（BAC）、肱动脉扩张性（BAD）明显降低（P<0.01）。脉压为 60～100mmHg组的SVC、BAC、BAD比脉压为40～60mmHg组显著降低（P<0.01）。年龄≥65岁组比年龄<65岁组 SVC、BAC明显降低（P<0.01）， BAD变化不大( P>0.05)。不同病因和不同透析年限之间未发现有动脉弹性功能异常变化的差异(P>0.05)。相关分析显示SVC与BAD高度相关(r=0.718, P<0.01），脉压与 SVC、BAC、BAD均呈高度负相关，与BAD相关系数最大（r=-0.865, P<0.01）。结论 ESRD血液透析患者的动脉弹性功能普遍减退，并与脉压密切相关。

关键词: 动脉弹性功能, 血液透析, 高血压

Abstract:

Objective To investigate arterial elastic function of hemodialysis patients with end-stage renal disease (ESRD). Methods One hundred and seventy-two chronic hemodialysis patients with ESRD were detected before dialysis by Dynapulse200M. Results Systemic vascular compliance (SVC), brachial artery compliance (BAC) and brachial artery distensibility (BAD) of hemodialysis patients were significantly reduced in comparison to the normal standard (P<0.01). SVC, BAC and BAD of patients with pulse pressure at the level of 60～100mmHg were higher than those of patients with pulse pressure at the level of 40～60mmHg (P<0.01). Between the two groups(age≥65years and age<65years), the former had lower SVC and BAC than the latter (P<0.01), There was no significant difference of BAD (P>0.05). There was no significant change among different causes of disease and different years of hemodialysis (P>0.05). A significant correlation was found between SVC and BAD (r=0.718, P<0.01), SVC, BAC and BAD all had inverse relationship with pulse pressure, the correlation coefficient between pulse pressure and BAD was the strongest (r=0.865, P<0.01). Conclusions Arterial elastic function of hemodialysis patients with ESRD reduces prevalently, moreover, it has close relation with pulse pressure.

Key words: Hemodialysis, Hypertension 