中国血液净化

›› 2003, Vol. 2 ›› Issue (9): 497-499.

• 人工肝 • 上一篇    下一篇

人工肝支持系统治疗重型肝炎临床观察

吴兴柳 于立新   

  1. 529071 江门，广东省江门市中心医院感染科(吴兴柳)225300 泰州，江苏省泰州市人民医院肝科(于立新)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-09-19 发布日期:2003-09-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-09-19 Published:2003-09-19

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摘要： 目的 探索人工肝支持系统 (ALSS)治疗重型肝炎的临床疗效和机制。方法 对63例重型肝炎 患者应用ALSS治疗，并检测治疗前、后肝肾功能，内毒素含量等，比较重型肝炎不同类型及时期应用ALSS的治疗效果。结果 ALSS治疗后,重型肝炎患者肝肾功能明显改善,血内毒素由治疗前(60.27±10.54)ng/L降至治疗后(28.33±6.57)ng/Ｌ( P<0.001),但3 d后又升至（44.18±8.22）ng/L。急性亚急性重型肝炎应用ALSS治疗治愈好转率分别为100%、62.5%，慢性重型肝炎早、中、晚期治疗治愈好转率分别为90.91%, 72.22%,39.13%。结论 ALSS治疗重型肝炎疗效可靠,急性亚急性重型肝炎的治疗效果较好，慢性重型肝炎在早、中期治疗最为适宜。

关键词: 人工肝支持系统, 重型病毒性肝炎

Abstract:

Objective To study the efficacy as well as the mechanism of artificial liver support system (ALSS) in the treatment of hepatitis gravis. Methods Sixty-three patients suffering from hepatitis gravis were treated with ALSS. The liver and renal function and serum endotoxin level were examined before and after ALSS therapy, and the efficacy of ALSS treatment on the different stages and different types of hepatitis gravis were investigated. Results It showed that liver and renal function improved significantly after ALSS therapy. Endotoxin concentration decreased significanHy from (60.27±10.54) ng/L to (28.33±6.57) ng/L( P<0.001), but it increased to (44.18±8.22) ng/L after 3days. The response rates of acute and subacute hepatitis gravis were 100% and 62.5% respectively, and the response rates of chronic hepatitis gravis in early stage, middle stage and late stage were 90.91%、72.22%、39.13% respectively. Conclusions The ALSS is effective in treating hepatitis gravis. The efficacy of ALSS on acute and subacute hepatitis gravis is better than that on chronic hepatitis gravis. It is more suitable to use ALSS in early and middle stage of chronic hepatitis gravis. 

Key words: Hepatitis gravis