中国血液净化

›› 2003, Vol. 2 ›› Issue (9): 500-502.

• 人工肝 • 上一篇    下一篇

人工肝治疗终病肝衰竭的终末期肝病模型预后分析

江元森 王海霞 李学俊 谢俊强 庄 鹏 张绍全 邓 友 林国梅 姚集鲁   

  1. 510630 广州，中山大学附属第三医院人工肝研究室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-09-19 发布日期:2003-09-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-09-19 Published:2003-09-19

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摘要：

目的 通过观察应用终末期肝病模型（ MELD）对人工肝治疗终末期肝病预后的预测作用，探讨其 在临床的应用价值及人工肝支持系统在终末期肝病治疗中的效果。方法 43例患者随机分为治疗组与对照组，对其进行MELD评分，并对治疗组进行人工肝后评分，观察3个月后的死亡率。结果 治疗组中4例治疗前MELD评分大于40分者，3个月死亡率为100%，17例治疗前评分30～40分者3个月死亡率为53%，对照组中6例MELD评分大于40分者，3个月死亡率为100%，16例治疗前评分30～40分者3个月死亡率为87%，与治疗组相比 P<0.05。结论 MELD评分可以引入临床推广应用，人工肝治疗MELD评分在30～40分的终末期肝病是安全有效的。

关键词: 终末期肝病模型, 重型肝炎, 人工肝

Abstract:

objective To study the practical use of model for end-stage liver disease(MELD)on clinic and the role of artificial liver support system (ALSS)on end-stage liver disease. Methods Fourty-three patients were divided randomly into treatment group and control group, and they were graded with MELD before and after ALSS. The death rate was observed three months later.
Results In the treatment group,4 cases with MELD score higher than 40 before treatment of ALSS were all dead after 3 months, and 17 cases with MELD score between 30 and 40 remained a death rate of 53%;In the control group,6 cases with MELD score higher than 40 were all dead too, and the death rate of 16 cases with MELD score between 30 and 40 was 87% 3 months later; There were significant difference compared with the treatment group, (P<0.05). Conclusions MELD can be popularized in clinic and ALSS can be used safely and effectively to treat end-stage liver disease with MELD score between 30 and 40.

Key words: Severe hepatitis, Artificial liver 