中国血液净化

›› 2004, Vol. 3 ›› Issue (1): 12-14.

• 论著 • 上一篇    下一篇

透析液流量、血液流量和温度对空心纤维透析器面积相关溶质转运系数影响的机制研究

李保春 崔若兰 郭志勇 许 静 翟振燕
  

  1. 200433 上海，上海第二军医大学第一附属医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-01-19 发布日期:2004-01-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-01-19 Published:2004-01-19

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摘要：

目的 探讨透析液流量、血液流量对空心纤维透析器面积相关溶质转运系数 (mass transfer area coefficient，KoA）影响的机制。方法 Syntra 160 的空心纤维密封端被分为4个同心圆，每个同心圆的面积相同。每次将4个同心圆的3个用Eposy密封。血流量选择为120 ml/min，透析液流量为500、800、1000ml/min。体外条件下，将空心纤维透析器分成四个等面积同心圆，直接测定不同区域的KoA；并用MRI方法定量测定透析器不同部位透析液流量和血流量的分布情况。结果 随着透析侧液体流量(Qd)的增加，KoA值在不同的等面积同心圆所占的百分比基本不变。MRI证明不同部位同心圆的透析液流量相近，Qd增加，各同心圆透析液流量所占透析液总流量比例不变。结论 溶质的KoA值随透析液流量增加而增加可能是由于透析液侧的液体不流动层减薄所致。

关键词: 血液透析, 透析器, 面积相关溶质转运系数

Abstract:

Objective To study the potential mechanism of the influence of the dialysate flow rate, blood flow rate on hollow fiber dialyzers mass transfer area coefficient. Method We measured KoA for different spatial locations in Syntra 160 dialyzer by selectively sealing the blood-side inlets except one concentric rings where fluid was allowed to enter. The blood flow rate was 120ml/min, the dialysate flow rate was 500、800、1000ml/min respectively. Flow sensitive magnetic resonance images of the dialyzers were used to neasure either blood-side or dialysate-side flow at the different rates Qb and Qd to determine the spatial variation of flow. Result The KoA values in different rings were nearly the same percent in total KoA value when increasing Qd. The MR images demonstrated that the velocity of dialysate increased with increasing Qd but that the distribution of flow remained constant for a given dialyzer. Conclusion The cause of the increase in KoA with increasing Qb may be due to a decrease of the boundary layer at the dialysis side.

Key words: Dialyzer, Mass transfer area coefficient

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