中国血液净化

›› 2004, Vol. 3 ›› Issue (1): 18-20.

• 论著 • 上一篇    下一篇

血液透析患者血清白蛋白水平与系统炎症反应的相关关系

姚 英 刘惠兰 张香玲   

  1. 100038 北京,首都医科大学附属复兴医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-01-19 发布日期:2004-01-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-01-19 Published:2004-01-19

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摘要： 目的 研究血液透析患者血清白蛋白水平与系统炎症反应的关系。 方法 选择56例维持性血液透析患者，根据血清白蛋白（Albumin, Alb）水平分为两组：Alb<40g/L组和Alb≥40 g/L 组，比较两组白细胞介素6（interleukin-6, IL-6）、超敏C反应蛋白（high sensitive C-reactive protein, hs-CRP）和纤维蛋白原水平，并进行相关性分析。结果 Alb<40g/L组IL-6、hs-CRP和纤维蛋白原水平均较Alb≥40g/L组高，差异具有非常显著性(P<0.01)。多元回归分析在矫正了年龄的影响后， IL-6是血液透析患者血清白蛋白水平的独立影响因素。 结论 血液透析患者血清白蛋白水平与系统炎症反应密切相关，提示血液透析患者营养不良的发生与存在的系统炎症反应有关。

关键词: 低蛋白血症, 炎症, 血液透析

Abstract: Objective To evaluate the relationship between inflammation and serum albumin levels in hemodialysis patients. Methods Serum albumin of 56 hemodialysis patients were measured and serum interleukin-6(IL-6), high sensitive C-reactive protein(hs-CRP)and fibrinogen concentration served as inflammation indexes were measured at the same time. Results Serum IL-6,hs-CRP and fibrinogen concentration were significantly higher in patents with serum albumin level lower than 40g/L(P<0.01).In a stepwise multivariate regression analysis, adjusting for age,significant association was observed between serum albumin level and IL-6 concentration. Conclusion The presence of inflammation is associated with the serum albumin level in hemodialysis patients.

Key words: Inflammation, Hemodialysis 

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