关键词: 尿毒症, 血液透析, 血清瘦素

Abstract: Objective To investigate the relationship between the leptin levels of chronic renal failure patients(before and after hemodialysis) and those of normal controls. Methods Thirty CRF patients(before and after hemodialysis) and thirty healthy control subjects were selected for the study, blood was drawn after an overnight fast. Leptin levels were determined by radioimmunoassay. There were also blood tests to measure BUN, creatinine, serum albumin etc. Results There were no significant differences between the leptin levels of CRF patients before hemodialysis and those of the controls, and the leptin levels in both groups correlated positively with body mass index(BMI), the leptin levels in females were significantly higher than in males; There were significant differences between the leptin levels of CRF patients after hemodialysis and those of the controls, hemodialysis group had significantly higher concentration of BUN, creatinine. No significant correlations were observed in hemodialysis group between the leptin levels and BUN, creatinine or serum albumin. There were no significant differences of leptin levels in those patients (before and after hemodialysis). Conclusion There were no significant differences between the leptin levels of CRF patients before hemodialysis and those of the controls, but CRF patients (after hemodialysis) are contrary. The leptin levels in females were significantly higher than in males. No significant correlations were observed in hemodi-alysis patients between leptin and malnutrition. Hemodialysis couldn't reduce the leptin concentrations.

Key words: Hemodialysis, Leptin 