目的 观察人工肝支持系统（ALSS）治疗重症肝炎的临床疗效。方法 应用血浆置换(PE)，胆红 素吸附及连续性静脉-静脉血液滤过(CVVH)对重症肝炎进行治疗，评价临床疗效并观察治疗前后TBIL、ALB、G、ALT、AST、ALP、PTA、BUN、Scr及凝血酶原活动度（PTA）等指标。结果 ALSS可显著改善患者临床症状，治疗前后血清胆红素水平降低(P<0.01）， PTA明显改善（P<0.05）， PE、CVVH能降低血清ALT、AST、ALP水平，胆红素吸附对血清ALT、AST、ALP水平影响不大( P>0.05)。结论 ALSS可显著改善重症肝炎患者临床症状及生化指标，提高近期存活率。

Objective To investigate the effect of artificial liver support system (ALSS) intreating hepatitis gravis. Methods The patients with severe hepatitis were treated with plasma exchange (PE), bilirubinadsorption and continuous veno-venous hemofiltration (CVVH), The improvements in clinical symptom and serum level of TBIL、ALB、G、ALT、AST、ALP、BUN、Cr and PTA were measured. Results ALSS can improve clinical symptoms and the level of serum bilirubin of patients with severe hepatitis were significantly decreased (P<0.01）, the serum level of ALT、AST、ALP in cases treated with PE and CVVH significantly decreased (P<0.05) while there was no change in patients treated with bilirubin adsortion (P>0.05). PTA were improved (P<0.05). Conclusion ALSS may impvere the clinical symptoms and biochemical indexes of severe hpatitis patients. 