Objective To investigate the effect of intravenous amiodarone on treating tachyarrythmia happened during hemodialysis. Methods Fifteen severe acute and chronic renal failure patients, including 6 male and 9 female, whose age averaged (55±21.5) years, occured tachyarrhythmia 22 times during hemodialysis. They were given introvenous amoiodarone for 50～100mg showly, then continuous intravenous drip for 100～150mg at the dose of 8～24μg/kg/min and repeated if necessary. The patients' symptoms, heartrate, cardiac rhythm and QT interphase were obserred and compared with 15 nondialysis controls. Results Thirteen times (59.1%) of the 22 tachy arrhythmia recovered sinus rhythm and the heart rates decreased to less than 100 pulse/min in 15 minutes, 6 times (27.3%) in 15～30 minutes and 3 times (13.6%) could not recover sinus rhythm in 30 minutes, but their heart rates decreased to 120～130 pulse/min and recovered sinus rhythm after supplementing potassium and intravenous injection of 0.2mg cedilanid. Patients' symptoms relieved quickly. There was no significont difference of QT interphase after therapy (P>0.05). One patient occured bradycardia and recovered after stopping amiodarone. There was no significant difference of therapy effect compared with the controls(P>0.05). Conclusions intravenous amiodarone is an effective and safe management of the serious tachyarry-thmia caused by hemodialysis.