关键词: 终末期肾病, 血液透析, 氧化应激

Abstract: Objective To study the effects of reusing d ialyzer on oxidative stress status in chronic hemodialysis (CHD) patients. Methods Fifty-five end stage renal disease (ESRD) patients who received hemodialysis therapy with cellulose menbrane for 4 weeks were divi ded into two groups randomly. Group I received hemodialysis with new cellalose m embrane. While the patients in group II reused dialyzer for four weeks. Twenty-t wo healthy adults were regarded as normal controls. MDA, e-SOD and GSH-px levels were compared between ESRD patients and normal controls, before and after asing le hemodialysis session and the two groups with new dialyser and reused dialyzer. Results The levels of MDA in plasma and erythrocyte in ES RD patients were significantly higher while the levels of SOD i n erythrocyte and GSH-px in plasma were lower than those of normal controls (P<0.05). The marker of oxidative stress did not change significant ly after primary hemodialysis, but the MDA level in erythrocyte increased signif icantly in group I, while deceased gently in group II. The SOD level in erythrocyte increased significantly in both two groups. Conclusion Oxidative stress is increased in patients with ESRD, which might be accelerated by chronic hemodialysis, but decreased by reuse dialyzer.

Key words: Hemodialysis, Oxidat ive stress