目的 研究血液透析患者透析间期体重获得量(IDWG%)与患者预后的关系。方法 回顾性研 究我中心1995年至2003年期间规律血液透析的患者144例。计算5年存活率、半数生存期，分析影响IDWG％的因素。用Cox模型分析患者的年龄、性别、血白蛋白水平、IDWG ％与患者生存预后的关系，并比较不同IDWG％分组之间死亡原因 的差别。结果 患者总体的5年存活率为52.1%，不同IDWG％分组之间存活率 分别为31.9％和57.3%，有显著差异（P=0.002）。在 Cox分析中，患者的 年龄、性别、血白蛋白水平、IDWG％均被接纳进入模型，低IDWG％的相对危险度为1.34。两组的死亡原因差别无显著性差异。结论 患者的存活率与水摄入量有关，高的水摄入量水平伴随低的死亡风险，并且这一关系独立于患者年龄、性别和血白蛋白水平之外。

Objective To study the relationship between interdialytic weight gain (IDWG%) and patients survival. Methods A retrospective study was performed with 144 stable hemodialysis patients treated in our center during 1995 and 2003. Patients were divided into two groups, group A (IDWG%≤6％) and group B (IDWG%＞6％). Life table and Cox's proportional hazard model were used to determine the hazard fac tors. Results For the entire study cohort, the mean IDWG% was 5 .83％. Five-year survival rate was poorer in group A (31.9％ vs. 57.3%, P=0.002). IDWG% was enrolled in Cox model even after adjusting the effects of patient's age, gender and serum albumin level. The relative risk was 1.34 (P=0.003). Conclusions IDWG% is a hazard factor to hemodialysis patients, a greater IDWG% is associated with a better prognosis. This relationship is valid even after the adjustment of patient's age, gender and serum albumin level.