中国血液净化

›› 2004, Vol. 3 ›› Issue (7): 355-357.

• 论著 • 上一篇    下一篇

米诺地尔在治疗血液透析伴顽固性高血压中的应用

刘双信 史 伟 梁馨苓 叶智明 何朝生 章 斌 梁永正 余学清   

  1. 510080 广州，广东省人民医院肾内科(刘双信，史伟，梁馨苓，叶智明，何朝生，章斌，梁永正)广州，中山大学附属第一医院肾内科(余学清)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-07-12 发布日期:2004-07-12
  • 通讯作者: 史伟

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-07-12 Published:2004-07-12

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摘要： 目的 探讨米诺地尔在维持性血液透析患者中的降压作用。 方法 11例血液透析伴顽固 性高血压患者，在服用常规降压药基础上使用米诺地尔，分析其的降压效果及其副作用。结果 米诺地尔治疗1月后显效率95％（10／11），有效率100％（11／11）；治疗3月后显效率100％。近期对血肌酐无明显影响。副作用观察：当患者服用的剂量为5.0mg/d时，其在一月后都出现不同程度的多毛现象；当米诺地尔剂量为2.5mg/d时，患者多毛有所减少。未见明显心率增快、心包积液及水钠潴留。结论 小剂量米诺地尔在配合其它降压药的基础上，对伴顽固性高血压的血液透析患者降压效果肯定，副作用可以耐受。

关键词: 血液透析, 高血压, 米诺地尔

Abstract: Objective To investigate the effect of minoxidil for hemodialysis patients with refractory hypertension. Methods Eleven hemodialysis patients with refractory hypertension were treated with minoxidil and other antihyperten-sive medicine. The effect and side-effect were analyzed. Results The obvious efficiency rate is 95%(10/11), and efficiency rate is 100%(11/11) after one month of minoxidil treatment. There was no effect on renal function in hemodialysis patients during the minoxidil treatment. When the dose of minoxidil was 5mg/d, hair growth was present in all patients after one month of treatment. When the dosage decreased to 2.5mg/d, hair growth slowed down in patients. Reflex increase of heart rate, pericardial effusion and fluid retention was not found during minoxidil treatment. Conclusion Minoxidil is highly effective in the management of severe hypertension with other antihypertensive medicine in hemodialysis patients, and the side-effects can be accepted by hemodialysis patients.

Key words: Hypertension, Minoxidil

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