目的 观察血液灌流对血液透析患者血脂［Lp(a)］的影响。方法 选取多个血液净化中心血液透析 患者40例，比较单次血液透析串联血液灌流前后患者血脂的变化。结果 慢性肾衰竭患者多数存在血脂代谢的紊乱，血液灌流后血 Lp(a)以及甘油三酯（TG）的浓度下降，高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A(APOA)、载脂蛋白B(APOB)、总胆固醇（TC）的浓度无明显变化。结论 血液灌流可以降低维持性血液透析患者的Lp(a)及TG，改善其脂代谢紊乱。

Objective To investigate the effect of hemoperfusion (HP) on lipids in hemodialysis patients with chronic renal failure(CRF). Methods To compare the differences of lipids in 40 hemodialysis patients with CRF before and after the treatment of combined hemodialysis-hemoperfusion. Results Lipid disorders are common in patients with CRF. The levels of triglyceride(TG) and lipoprotein(a)［Lp(a)］ in serum decreased after the treatment of combined hemodialysis-hemoperfusion. The levels of cholesterol(TC)、high-density lipoprotein(HDL)、low-density lipoprotein(LDL)、apolipoprotein A (APOA)、APOB had no significant changes after treatment. Conclusion Hemoperfusion is a method of an effective treatment in dyslipidemia of hemodialysis patients.