中国血液净化

›› 2005, Vol. 4 ›› Issue (2): 67-69.

• 论著 • 上一篇    下一篇

尿毒症维持性血液透析患者C-反应蛋白变化及临床意义

李全瑞 郭增玉 陈秉良 冯 明 张 沛   

  1. 100053 北京，首都医科大学附属宣武医院综合科(李全瑞，陈秉良，冯明)，肾内科(张沛)101200 平谷，北京市平谷医院肾内科(郭增玉)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-02-12 发布日期:2005-02-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-02-12 Published:2005-02-12

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摘要：

目的 探讨尿毒症维持性血液透析患者C-反应蛋白的改变及相关临床意义。方法 抽取21 例尿毒症维持性血液透析患者血液透析前和血液透析后的C-反应蛋白（CRP）、血肌酐（SCr）、血清白蛋白（ALB）、血红蛋白（Hb）及18例健康者作为对照组。结果 尿毒症维持性血液透析患者透析前CRP正常与异常组之间ALB、Hb 差异有显著性( P＜0.05)，透析后 CRP水平升高、血液透析前与血液透析后比较差异有显著性( P＜0.05)，且血液透析后患者 CRP与其ALB、Hb显著负相关( P＜0.05)。结论 CRP 升高发生炎症反应在维持性血液透析患者营养不良、贫血中起重要作用，且CRP升高发生炎症反应与血液透析本身的因素及个体因素如感染、营养状况等相关。

关键词: 血液透析, 尿毒症, C-反应蛋白

Abstract:

Objective To study the clinical significance of changes of C-reative protein(CRP). Methods Their CRP,Serum creatinine(SCr), albumin(ALB), Hemoglobin(Hb) were measured twenty-one maintenance hemodialysis patients and 18 normal controls were investigated. Results There were significant difference (P<0.05) of serum AlB and Hb between normal CRP patients and abnormal CRP patients before CRP patients before hemodialysis. The level of serum CRP increased after hemodialysis. The difference of CRP level before and after hemodialysis was significant (P<0.05). Negative correlation was found between the levels of CRP and ALB and Hb after hemodialysis ( P＜0.05). Conclusion The increasing CRP levels resulted in inflammatory state of uremia patients and that played a role in the occurance of malnutrition and anemia of maintenance hemodialysis patients. The increasing of CRP level and inflammatory reaction are correlated with some factors of hemodialysis and patients such as infection, nutrtional status etc.

Key words: Uremia, C-reactive protein 

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