中国血液净化

›› 2005, Vol. 4 ›› Issue (2): 93-95.

• 论著 • 上一篇    下一篇

肾性贫血与氧化应激的关系

赵素梅 彭立人   

  1. 100020 北京，首都医科大学附属北京朝阳医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-02-12 发布日期:2005-02-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-02-12 Published:2005-02-12

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摘要：

目的 探讨肾性贫血与氧化应激的关系。 方法 慢性肾功能不全（CRF）患者68例，排除原发 病为糖尿病肾病患者，实验阶段未患感染性疾病，实验前未接受过正规治疗，根据其血红蛋白（Hb）数值分为2组。第1组33人，HB>90g/L，男18例，女15例，年龄38～71岁；第2组35人，男16例，女19例，年龄21～71岁，HB≤90g/L，则定患者血脂质过氧化物（LPO）、超氧化物歧化酶（SOD）、血胆固醇（CHO）、甘油三酯（TG）、血清白蛋白（ALB）及尿素氮（BUN）、肌酐（SCr）水平；测定用促红细胞生成素、铁剂、VitE和VitC治疗后第2组患者血LPO、SOD水平。结果 第1组血LPO水平明显低于第2组， P<0.05； SOD水平明显高于第2组， P<0.05，第1组血 ALB、胆固醇水平明显高于第2组， P<0.05，血甘油三酯及血小板水平第1组也高于第2组，但无显著差异。第2组治疗前后血 LPO、SOD水平具有显著差异。血红蛋白与LPO成负相关；与SOD成正相关。结论 红细胞内含有高效的自由基清除剂，故肾性贫血时由于SOD减少，可加重氧化应激，导致LPO产生增多；提高血红蛋白并给予抗氧化剂治疗后氧化应激可得到改善。

关键词: 氧化应激, 肾性贫血, 脂质过氧化物, 超氧化物歧化酶

Abstract:

Objective To investigate the relationship between oxidative stress and renal anemia. Methods Sixty-eight chronic renal failure patients with the exception of diabetic nephropathy were enrolled. All patients had not suffered from disease of infection in the periods of experiment and had not accepted the formal treatment.Based on the level of hemoglobin (HB), they were divided into 2 groups: were 33 patients with HB>9g/dl in group 1,including 18 male and 15 female,age ranged from 38 to71 and 35 patients with HB≤9g/dl in group 2,16 male and 19 female,age ranged from 21 to 71. lipid peroxidation (LPO),superoxide dismutase(SOD), serum cholesterol(CHO), triglyceride(TG), albumin, creatinine and urea nitragen were measured. The Lpoand SOD of group 2 patients were detected again after being treated with erythropoiesis iron, vitc and vit E. results LPO concentration in group 1 patients was significantly lower than that of group 2 patients ( P<0.05), the SOD, serum albumin and CHO were higher than those of group 2 patients( P<0.05). The level of TG and PLT in group 1 were higher than group 2( P>0.05). LPO and SOD levels in group 2 patients were significantly different before and after treatment. HB was negatively correlated with LPO and positively or related with SOD. Conclusion Erythrocytes contains highly effective free radical scavengers. When renal anemia present, Decreased SOD can reduce increased oxidative stress and LPO products; Oxidative stress was improved by correction of the renal anemia and supplement of antioxidant.

Key words: Renal anemia, Lipid peroxidation, Superoxide dismutase 