目的 观察用丽珠HA型树脂吸附血液灌流器行血液灌流（ HP）治疗肝性高胆红素（TBil≥171 μmol/L）血症的疗效和安全性。方法 选择肝性高胆红素血症患者48例，观察血液灌流治疗前后的 胆红素变化情况，评价灌流术的安全性。结果 血液灌流术后TBil较术前明显下降，经统计学处理有显著差异（ P<0.01）；血液灌流术不良反应发生率为35.4%（主要是血压下降20.83%，恶心/呕吐16.67%）。结论 树脂吸附血液灌流器治疗肝性重度高胆红素血症有较满意疗效和较好安全性，可明显改善症状及缩短平均住院时间。

objective To observe the curative effects and safety of HA sterile hemoperfusion cartridge in the treatment of hepatic hyperbilirubinemia(TBil 171μmol/L). Methods 48 patients with hepatic hyperbilirubinemia were treated with HA sterile hemoperfusion catridge.The changing level of bilirubin were observed. Results TBil decreased obviously after hemoperfusion ( P<0.01); The rate of adverse-reaction was 35.4% after hemoperfusion:The rate of blood pressure falling was 20.83%;The rate of nausea or vomiting was 16.67%. Conclusion Our date suggest that hemoperfusion therapy is an effective and safe treatment for hepatic hyperbilirubinemia and can improve the symptom and may shorten the recovery time.