中国血液净化

›› 2005, Vol. 4 ›› Issue (9): 494-496.

• 论著 • 上一篇    下一篇

一次性使用树脂吸附柱治疗尿毒症的临床观察

卢方平 卢照翾   

  1. 100016 北京，清华大学第一附属医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-09-12 发布日期:2005-09-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-09-12 Published:2005-09-12

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摘要： 目的 探讨1次性使用树脂吸附柱治疗尿毒症患者的疗效与安全性。方法 维持性血液透析患者31例，采用血液灌流与血液透析（HP/HD）联合治疗方法与常规血液透析（HD）方法对比（自身对照）。治疗前后检测中分子物质（MMS）、血尿素、肌酐、白蛋白、血细胞及临床症状。结果 树脂吸附柱治疗血液透析患者能显著清除尿毒症患者体内的中分子物质，单次使用治疗2hMMS平均下降25.0%，最高达44.4%。而普通透析对MMS无多大影响，两者差异具有显著性（P＜0.001）。同时患者的睡眠、食欲、皮肤瘙痒有不同程度的改善。未发生其他任何不良事件和副作用。结论 作为MMS的清除治疗措施，1次性使用树脂吸附柱临床使用安全、疗效可靠，无毒副反应。

关键词: 血液灌流, 血液透析, 尿毒症, 中分子毒素

Abstract: objective To investigate the effect and safety of combined hemodialysis- resin hemoperfusion in uremia. Methods Thirty-one uremia patients were treated with combined hemodialysis-resin hemoperfusion. Middle molecular substances(MMS), urea and creatinine were detected before and after the treatment. Meanwhile, we compared the effect of combined hemodialysis- resin hemoperfusion procedure with conventional hemodialysis in uremic toxin clearance. Results MMS was reduced significantly in combined hemodialysis-hemoperfusion procedure (P ＜0.001). Compared with conventional hemodialysis, a combination of hemoperfusion and hemodialysis had a better effect in MMS clearance (P ＜0.001). Meanwhile, some clinical conditions (appetite, pruritus, insomnia) improved. We did not found any adverse effect. Conclusion Resin hemoperfusion can effectively clean MMS and was confirmed to be a safe and risk-free procedure.

Key words: Hemodialysis, Uremia, Middle molecular substances

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