血浆置换联合拉米夫定对重型肝炎HBV动力学影响

鲍旭丽; 段钟平; 单晶; 韩大康; 赵军

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中国血液净化 ›› 2006, Vol. 5 ›› Issue (1) : 41-43.

人工肝

血浆置换联合拉米夫定对重型肝炎HBV动力学影响

鲍旭丽段钟平单晶韩大康赵军

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摘要

目的观察血浆置换(PE)联合拉米夫定(LAM)治疗慢性重型乙型肝炎对HBV造成的影响。方法选择首都医科大学附属北京佑安医院人工肝中心11例慢性重型乙型肝炎患者随机分为血浆置换与拉米夫定联合、单纯拉米夫定2组，治疗12周，观察治疗前、治疗后一系列病毒载量的变化。结果第1组的抑制病毒生成效率范围为38.2%～74.6%，平均55.0%，第2组的抑制病毒产生效率范围为67.6%～89.7%，平均75.1%。对2组效率进行t检验，差异有显著性。结论提示PE联用LAM可以在PE后较低病毒血症水平的基础上发挥LAM对病毒的抑制作用，巩固PE对病毒的清除作用，抑制病毒复制的效率较高。

Abstract

Objective To observe the influence to HBV in peripheral blood of Lamivudine combined with plasma exchange. Methods Eleven cases with chronic severe hepatitis B were enrolled and receiced Lamivudine or Lamivudine combined with plasma exchange treatment for 12 weeks. Results There was significant difference of mean antiviral efficacy between the two groups. Conclusion Combinaed therapy of PE and LAM has higher efficacy than LAM alone for inhibiting HBV replication.