复用透析器患者丙型肝炎病毒交叉感染临床研究

范文奎; 梁艳影

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中国血液净化 ›› 2006, Vol. 5 ›› Issue (5) : 236-237.

论著

复用透析器患者丙型肝炎病毒交叉感染临床研究

范文奎梁艳影

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摘要

目的采用有效的杀菌方法减少复用透析器患者(Hepatitis C virns,HCV)的交叉感染。方法应用Renalin100作为复用透析器的杀菌剂，采用Renatro PA 100全自动复用机进行透析器复用，HCVIgM阳性患者透析器一次性应用，HCVIgG阳性透析器复用，但与阴性患者透析器分机复用处理和隔离储存。检测全部复用透析器患者的HCVIgM和HCVIgG，检测间隔时间6个月，总观察时间3年，比较分析检测结果。结果定时检测，各组之间比较，HCVIgG阳性率差异无显著性(P＞0.05)，HCVIgM阳性患者均为0例。退出观测者末次检测分析，HCVIgM阳性患者为0例，HCVIgG阳性数在退出者与定时检测总数之间比较差异无显著性(P＞0.05)。结论应用Renalin100作为复用透析器的杀菌剂，采用Renatro PA 100全自动复用机进行透析器复用，HCVIgM阳性患者透析器一次性应用，HCVIgG阳性透析器复用，但与阴性患者透析器分机复用处理和隔离储存，对防止血液净化中心的复用透析器患者HCV交叉感染有效。

Abstract

Objective To investigate a reasonable way for reducing HCV infection in hemodialysis patients dialyzed with reused dialyzer. Methods Dialyzers were reused with Renalin 100 as disinfectant and Renatro PA 100 The dialyzers of HCV Igm positive patients were for single use.Dialyzers of anti HW IgG positive patients were reused and stored seperately with those of anti-HW IgG negative patients. All patients were examined HCV IgG and HCV IgM at an interval of 6 months in 3 years. Results The results of HCVIgG were similar in both groups（P＞0.05）. The number of HCVIgM positive patient was 0 in all patients. The incidence of positive anti-HCV IgG was similar between all retreating patients and all examined patients(P＞0.05). Conclusion Using Renalin100 to disinfect the reused dialyzer and Renatro PA 100 to reuse the dialyzers, using the dialyzers of anti-HCV IgM positive patients once, reusing the dialyzers of anti-HCVIgG positive patients seperately with those of anti-HCVIgG negative patients, could prevent HCV infection. The way is safe and effective.