中国血液净化

›› 2006, Vol. 5 ›› Issue (8): 413-415.

• 论著 • 上一篇    下一篇

血液透析患者的主动脉瓣钙化

朱爱国 陈 琬 曹如画 鲍恩昊   

  1. 201200 上海，上海市浦东新区人民医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-08-12 发布日期:2006-08-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-08-12 Published:2006-08-12

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摘要： 目的 探讨血液透析患者主动脉瓣钙化及钙化所致的瓣膜狭窄的发生发展及其对心脏功能的影响。方法 通过心脏超声检查观察上海市浦东新区人民医院110例终末期肾病(ESRD)血液透析患者主动脉瓣膜钙化程度、瓣口面积及相关的生化指标，同时选择100例无肾脏疾病、无风湿性疾病的患者作对照组。结果 ESRD患者组发现主动脉瓣钙化48例，占43.64%，发生瓣膜钙化的平均年龄(56.4±14.6)岁；对照组发现主动脉瓣钙化22例，占22%，平均年龄(68.5±10.3)岁。主动脉瓣钙化所致主动脉瓣狭窄ESRD患者组9例、对照组2例。ESRD组钙化者(AVC)的平均透析龄为(33.37±27.6)月，ESRD组无钙化者的平均透析龄为(20.82±18.6)月，(P＜0.05)。结论 慢性肾衰竭血液透析患者主动脉瓣钙化发生率高、进展至主动脉瓣狭窄快，主动脉瓣钙化发生、发展与继发性甲状旁腺功能亢进、高磷血症和透析年限有密切相关。

关键词: 终末期肾脏病, 血液透析, 主动脉瓣钙化

Abstract: Objective To observe aortic valve calcification in maintenance hemodialysis (MHD) patients and its effects on cordic struture and function. Methods One hundred and ten MHD patients and 100 normal controls who had no kidney disease or rheumatoid disease were enrolled. The calcification of aortic valve and aortic valve area was measured by color Doppler echocardiograms. Results Of 110 MHD patients, 48(43.6%) were found aortic valve calcification 9 aortic valve stenosis by echocardiogram. Of 100 normal controls,22(22%) aortic valve calcification and 2 stenosis. Conclusion There is a high prevalence of aortic valve calcification in MHD patients.The risk factors in MHD patients are hyperphosphatemia, secondary hyperparathyroidism and longer duration of hemedialysis.

Key words: Hemodialysis, Aortic valve calcification

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