摘要
目的 探讨高通性血液滤过(HVHF)在严重脓毒血症治疗中的临床作用。方法 选择浙江省杭州市第一人民医院危重病医学科32例严重脓毒血症患者进行HVHF[流量80ml/(Kg·h)]治疗，观察治疗前后患者炎性介质(TNF-a、IL-6、IL-8、IL-10)、氧合指数、APACHE-Ⅱ评分、MODS评分、TFC的变化。结果 32例患者经HVHF首次治疗后氧合指数改善，APACHE-Ⅱ、MODS评分和TNF-a、IL-6、IL-8 也有明显下降，差异均有显著性(P＜0.05)，而IL-10无明显下降。经多次治疗后，最终患者TFC、APACHE-Ⅱ、MODS评分明显下降，有统计学意义（P＜0.05)。结论 HVHF可以改善严重脓毒血症患者的呼吸功能，改善患者的生命体征，并能缓解病情。
Abstract
Objective To evaluate the clinical efficacy of high-volume hemofiltration(HVHF) on treating severe sepsis. Methods Data of 32 patients with severe sepsis treated by HVHF were collected and the differences of oxygenation indices, APACHE-Ⅱscores, MODS scores and TFC before and after HVHF therapy were observed. Results After the first treatment HVHF, patients’ oxygenation indices improved apparently. APACHE-Ⅱscores,MODS scores and TNF-α,IL-6,IL-8 also decreased significantly(P ＜0.05). Yet IL-10 level did not decrease. After several times of HVHF treatments,finally patiants oxygenation indices apparently improved,APACHE-Ⅱscores,MODS scores and TFC decreased significantly (P ＜0.05).Conclusion HVHF can improve respiratory function of patients with severe sepsis, improve vital signs of patients and relieve the severity of the illness.
关键词
高通量血液滤过 /
脓毒血症
Key words
Sepsis
郑永科 刘长文 朱克毅 陆 俊 胡 炜 周 挺.
高通量血液滤过在严重脓毒血症中的临床分析[J]. 中国血液净化. 2006, 5(8): 416-417
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
PDF(282 KB)
