中国血液净化

›› 2007, Vol. 6 ›› Issue (10): 543-544.

• 论著 • 上一篇    下一篇

辛伐他汀对尿毒症非透析患者微炎症反应的影响

袁慧忠 喻春华 曹炎生 陈 健 谢 放
  

  1. 435002 黄石，湖北省黄石市第二医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-10-12 发布日期:2007-10-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-12 Published:2007-10-12

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摘要： 目的 探讨辛伐他汀治疗对尿毒症非透析患者微炎症反应的影响。方法 选择湖北省黄石市第二医院肾内科尿毒症非透析患者61例，随机分为他汀治疗组和对照组，监测治疗前、治疗后C反应蛋白(CRP)、白细胞介素-6(IL-6)和营养学指标的变化并选择22例健康志愿者作为正常对照。结果 与正常人组比较，治疗前尿毒症患者的CRP、IL-6水平显著升高(P＜0.05)，血浆白蛋白(ALB)、血浆前白蛋白(PALB)、血红蛋白(Hb)均显著降低(P＜0.05)。治疗后24周，他汀治疗组CRP、IL-6的水平均明显下降，Salb、Spalb、Hb明显升高，与治疗前及对照组相比，差异有显著性，P＜0.05和P＜0.05；同时患者血肌酐(SCr)、尿素氮(BUN)也呈下降趋势，但肌酐清除率(Ccr)、变化无显著性。结论 辛伐他汀治疗可以抑制尿毒症非透析患者的微炎症反应，改善营养状态。

关键词: 辛伐他汀, 尿毒症, 微炎症反应

Abstract: Objective To investigate the therapeutic effect of simvastatin on micro-inflammatory state in nondialysed patients with uremia. Methods Sixty-one nondialysed patients with uremia were randomly assigned into simvastatin group (n=31) and patient control group (n=30). Twenty-two healthy volunteers were also observed as the normal control group. Serum C-reactive protein (CRP), Interleukin-6 (IL-6) and nutritional indices were examined in patients before and after treatment for 24 weeks. Results In patients of simvastatin group before simvastatin treatment and patient control group, serum CRP and IL-6 were elevated (P＜0.05) but serum albumin (ALB), proalbumin (PALB) and hemoglobin (HB) were reduced(P＜0.05), as compared with those of normal control group. After simvastatin therapy for 24 weeks, CRP and IL-6 decreased and ALB, PALB and HB increased (P＜0.05), as compared with those before the treatment and those of patient control group. In simvastatin group, serum creatinine and urea nitrogen also declined slightly, but without changes of creatinine clearance rate. Conclusion Simvastatin relieves the microinflammation reactions and improves nutritional status in nondialysed patients with uremia.

Key words: Uremia, Microinflammation

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