中国血液净化

›› 2007, Vol. 6 ›› Issue (5): 249-252.

• 论著 • 上一篇    下一篇

急性肾衰竭患者血肾上腺髓质素的变化及临床意义

齐辰利 李荣山 李彩霞 邵 珊 程丽娟 高仁义 张 瑜 李元红 刘 静 成秀芬
  

  1. 030001 太原，山西医科大学第二医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-05-12 发布日期:2007-05-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2007-05-12 Published:2007-05-12

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摘要： 目的 观察急性肾衰竭(ARF)患者血肾上腺髓质素(ADM)的变化，及与炎症因子(CRP、IL-6、TNF-α)、肾功能(Scr)的相关性，探讨ADM在ARF炎症反应中的作用。方法 选择山西医科大学第二医院确诊的单纯ARF患者76例作为病例组，健康人25人作为对照组；统一检测血ADM、CRP、IL-6、TNF-α及Scr水平。结果 ARF患者血ADM、CRP、IL-6、TNF-α及Scr水平均高于正常对照组(P＜0.001)，且血ADM与炎症因子、肾功能水平呈显著正相关(P＜0.001)。结论 单纯型ARF患者血ADM水平增高，与炎症介质、Scr之间呈显著正相关，因此ADM可能参与了ARF的炎症反应与肾功能的改善。

关键词: 肾上腺髓质素, 急性肾衰竭

Abstract: Objective To observe changes of serum adrenomedullin (ADM) in acute renal failure (ARF) patients and its correlation to serum creatinine, C-reactive protein, IL-6 and TNF- . Methods Seventy-six cases of simple ARF treated in the Second Hospital of Shanxi Medical University and without having acute or chronic infection, malignancy, multiple organ failure, blood transfusion and glucocorticoid and immunosuppressant therapy were enrolled in this study. Twenty-five healthy individuals were used as the controls. Serum ADM, C-reactive protein, IL-6 and TNF- were determined by ELISA Results Serum ADM, C-reactive protein, IL-6, TNF- and creatinine were significantly high in the patients (P＜0.001, as compared with those of controls). The higher serum ADM was positively correlated with serum C-reactive protein, IL-6，TNF- , and creatinine (p<0.001). Conclusions Higher serum ADM was found in ARF patients and the higher serum ADM was positively correlated with serum creatinine and the inflammatory factors. In ARF patients, ADM may be involved in the inflammatory processes and renal function improvement.

Key words: Acute renal failure

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