左卡尼汀对维持性血液透析患者营养改善的国内相关文献Meta分析

刘红英; 陈湛华; 刘建新; 吴铜祥

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中国血液净化 ›› 2007, Vol. 6 ›› Issue (8) : 407-410.

论著

左卡尼汀对维持性血液透析患者营养改善的国内相关文献Meta分析

刘红英1 陈湛华2 刘建新1 吴铜祥1

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摘要

目的评价国内应用左卡尼汀治疗的维持性血液透析患者的营养状况。方法采用Meta分析对17篇国内相关文献进行定量综合分析。结果 17项研究共有768名血液透析患者入选，治疗组/用药后患者血红蛋白、血浆白蛋白、转铁蛋白、前白蛋白、左卡尼汀含量分别比对照组/用药前高0.25～0.51、0.41～0.79、0.44～0.75、0.13～0.75和1.90～4.49倍标准差，而治疗组患者血浆三酰甘油含量比对照组降低0.06～0.45倍标准差，总胆固醇含量较对照组降低不明显。结论用左卡尼汀治疗可有效地改善血液透析患者的营养状况

Abstract

Objective To assess the nutritional status in maintenance hemodialysis patients treated with L-carnitine. Methods A Meta analysis was made regarding the effect of L-carnitine on the improvement of nutritional status in maintenance hemodialysis patients from 17 related reports observed in China. Results A total of 768 patients in the 17 reports were analyzed. The levels of hemoglobin, serum albumin, transferrin, pro-albumin and serum L-carnitine in the treatment (or post-treatment) group were 0.25～0.51, 0.41～0.79, 0.44～0.75, 0.13～0.75 and 1.90～4.49 times higher than their respective standard deviation of the control (or pre-treatment) group. Serum triglycerides were 0.06～0.45 times less than the standard deviation of the control group, but total cholesterol did not decreased significantly. Conclusion The nutritional status of maintenance hemodialysis patients improved after L-carnitine treatment.