中国血液净化

›› 2008, Vol. 7 ›› Issue (10): 542-545.

• 论著 • 上一篇    下一篇

血液透析患者血清Fractalkine、TIMP-1水平的变化及意义

王 玲 林洪丽 赵光本 乔世岩 王可平 杭宏东 于长青   

  1. 116021 大连，辽宁省大连市第五人民医院血透室
  • 收稿日期:2008-06-03 修回日期:1900-01-01 出版日期:2008-10-08 发布日期:2008-10-08

The significance of serum fractalkine and TIMP-1 changes in maintenance hemodialysis patients

WANG Ling, LIN Hong-li, ZHAO Guang-ben, QIAO Shi-yan, WANG Ke-ping, HANG Hong-dong, YU Chang-qing   

  1. 1 Department of Nephrology, the Firt Affiliated Hospital of Dalian Medical Universty. 2 Hemodialysis Unit, Dalian the 5th People's Hospital, Dalian, Liaoning 116021, China
  • Received:2008-06-03 Revised:1900-01-01 Online:2008-10-08 Published:2008-10-08

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摘要： 目的 测定维持性血液透析(MHD)病人血清Fractalkine(FKN)及金属蛋白酶组织抑制剂-1（TIMP-1)水平的变化，探讨FKN、TIMP-1与炎症的关系。方法 选取长期规律血液透析(HD)的病人30例，应用ELISA法检测其透析前、后的FKN、TIMP-1血清水平，应用免疫散射比浊法测定透析前血清超敏C反应蛋白（Hs-CRP)水平，同时检测其血白蛋白(ALB)、血红蛋白(Hb)、体重指数（BMI)、透析充分性指标（Kt/V)及透析前后尿素氮(BUN)、肌酐（Scr）水平。结果 MHD病人HD后的血清FKN水平比HD前升高（P＜0.01），HD后的TIMP-1水平比HD前升高（P＜0.01）。HD前血清FKN水平与HD前Hs-CRP呈正相关(r=0.387, P＜0.05)，HD前血清FKN与HD前TIMP-1、透析年限无相关性（P＞0.05）；HD前TIMP-1水平与HD前Hs-CRP、透析年限无相关性（P＞0.05）。HD前后FKN差值与HD前Hs-CRP呈正相关（r=0.291，P＜0.05），与HD前后TIMP-1差值及透析年限无相关性（P＞0.05）；透析前后TIMP-1差值与HD前Hs-CRP呈正相关（r=0.226，P＜0.05），与透析年限无相关性（P＞0.05）。结论 血液透析病人透析后血清FKN及TIMP-1水平增高。HD前后FKN及TIMP-1水平的瞬时变化可能与炎症有关。

关键词: 金属蛋白酶组织抑制剂-1, 血液透析, Fractalkine, 微炎症状态

Abstract:

Objective To measure the changes of serum fractalkine (FKN) and tissue inhibitors of metalloproteinase-1 (TIMP-1) in maintenance hemodialysis (MHD) patients, and to discuss the relationship between inflammation and serum concentrations of FKN and TIMP-1. Methods We measured serum FKN and TIMP-1 by ELISA before and after hemodialysis in 30 MHD patients. Their serum high-sensitivity C-reactive protein (Hs-CRP) before hemodialysis was measured by immunonephelometry. Serum albumin (ALB), hemoglobin (HB), body mass index (BMI) and the dialysis adequacy marker Kt/V were also determined. BUN and serum creatinine (Scr) were assayed before and after hemodialysis. Results Serum FKN and TIMP-1 increased after hemodialysis (P<0.01, as compared with their respective values before hemodialysis). Before hemodialysis, their serum FKN and Hs-CRP were positively correlated (r=0.387, P<0.05), but their serum FKN did not correlated to serum TIMP-1 or to hemodialysis duration (P>0.05), nor did their serum TIMP-1 to Hs-CRP or to dialysis duration (P>0.05). The differences of serum FKN concentrations before and after hemodialysis were positively correlated to Hs-CRP (r= 0.291, P<0.05), but had no correlation with the differences of serum TIMP-1 concentrations before and after hemodialysis or to dialysis duration (P>0.05). The differences of serum TIMP-1 concentrations before and after hemodialysis were also positively correlated to Hs-CRP (r=0.226, P<0.05), and had no correlation with dialysis duration (P>0.05). Conclusion Serum FKN and TIMP-1 increase after hemodialysis in MHD patients. The instantaneous changes of serum FKN and TIMP-1 after hemodialysis may relate to the microinflammatory state.

Key words: Hemodialysis, Fractalkine microinflammatory state

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