中国血液净化

›› 2008, Vol. 7 ›› Issue (11): 595-598.

• 论著 • 上一篇    下一篇

血液透析患者血清抵抗素水平与微炎症状态及脂代谢的关系

张 睿 王 莉 李贵森   

  1. 四川省医学科学院 四川省人民医院肾内科
  • 收稿日期:2008-04-01 修回日期:1900-01-01 出版日期:2008-11-12 发布日期:2008-11-12

The correlation of serum resistin to microinflammatory state and dyslipidemia in patients with maintaince hemodialysis

ZHANG Rui, WANG Li, LI Gui-sen   

  1. Department of Nephrology, Sichuan Academy of Medical Sciences＆Sichuan Provincial People抯 Hospital, Chendu, 610072, China
  • Received:2008-04-01 Revised:1900-01-01 Online:2008-11-12 Published:2008-11-12

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摘要： 目的 观察维持性血液透析(MHD)患者血清抵抗素(resistin)水平，探讨其与炎症和脂代谢的关系。方法 用酶联免疫吸附试验（ELISA） 方法测定30例健康对照者以及30例血液透析患者透析前后血清抵抗素、生化指标及相关炎性因子水平。同时收集这些MHD患者的临床资料。分析抵抗素与上述指标的关系。结果 MHD患者较正常组血清抵抗素水平明显增高（5.88±2.54ng/ml vs.1.94±0.95ng/ml，P＜0.01），同时TG水平升高，HDL-C显著降低，胆固醇和LDL-C无明显差异；CRP、IL-6和VCAM-1水平较对照组明显增加。有心血管疾病的MHD患者血清抵抗素水平升高更为显著。患者血清抵抗素与CRP、IL-6、LDL-C和SGA成正相关，与HDL-C成负相关。结论 MHD患者血清抵抗素水平明显升高，可能与MHD患者的脂代谢紊乱，微炎症状态以及心血管疾病有关。

关键词: 抵抗素, 维持性血液透析, 炎症因子, 血脂, 心血管疾病

Abstract: Objective To investigate serum resistin in maintenance hemodialysis (MHD) patients and to explore its correlation to microinflammatory state and lipid metabolism． Methods Serum resistin, biochemical parameters and related inflammatory factors were determined by ELISA in 30 MHD patients before and after hemodialysis and in 30 healthy individuals. Clinical data were collected, and the relationship between serum resistin and the parameters was investigated. Results Serum resistin increased significantly (5.88±2.54ng/ml vs. 1.94±0.95ng/ml, P＜0.01) in MHD patients, especially in those complicated with cardiovascular diseases. In MHD group, serum triglyceride (TG) increased (P＜0.05), high density lipoprotein-cholesterol (HDL-C) decreased (P＜0.05), but serum cholesterol and low-density lipoprotein cholesterol (LDL-C) remained unchanged, as compared with those in control group. Serum C-reactive protein (CRP), IL-6 and vascular cell adhesion molecule-1 (VCAM-1) also increased significantly. In MHD group, serum resistin correlated positively with CRP (r=0.387, P＜0.05), IL-6 (r=0.432, P＜0.05), LDL-C (r=0.428, P＜0.05) and subjective general assessment (r=0.517, P＜0.05), and negatively with HDL-C (r=-0.451, P＜0.05). Conclusions MHD patients had higher serum resistin, which may relate to their dyslipidemia, microinflammatory status and cardiovascular diseases

Key words: Maintenance hemodialysis, Inflammatory factors, Lipid metabolism, Cardiovascular disease

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