中国血液净化

›› 2008, Vol. 7 ›› Issue (4): 179-182.

• 论著 • 上一篇    下一篇

平衡型氨基酸透析液血液透析治疗临床应用观察

李冀军 陈凤锟 王建红   

  1. 解放军总医院第一附属医院 肾内科 解放军总医院第一附属医院 肾内科 解放军总医院第一附属医院 肾内科
  • 收稿日期:2008-01-08 修回日期:1900-01-01 出版日期:2008-04-12 发布日期:2008-04-12

Clinical observation of dialysate containing balanced amino acids used in maintenance hemodialysis patients

  1. 1Nephrology Department, 2Burn Institute, The First Affiliated Hospital of PLA General Hospital, Beijing 100037,3Beijing siwei medicine and Technology Institute, Beijing 100022, China
  • Received:2008-01-08 Revised:1900-01-01 Online:2008-04-12 Published:2008-04-12

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摘要： 目的：设计平衡型氨基酸透析液，应用于维持性血透患者常规血透治疗，观察临床应用效果。方法：长期维持性血液透析患者29例，透析2-3次/周，在日常使用碳酸氢盐透析液基础上，应用氨基酸透析液1月后，分别观察血液生化指标、血浆蛋白、肾功能以及炎症指标的变化。结果：血浆氨基酸谱显示绝大部分游离氨基酸及总游离氨基酸含量均恢复到与健康人相仿的水平；平衡型氨基酸透析液治疗后尿素氮、肌酐、尿酸等肾功能指标有不同程度的升高，但电解质及钙、磷没有明显的变化；血浆TP、ALB、PreA、Trf等较前无明显变化，但β2-MG和SCRP则较应用前有明显的降低（P<0.01和P<0.05）。结论：平衡型氨基酸透析液能减少维持性血透患者的氨基酸丢失，改善其体内的氨基酸代谢紊乱，同时可减轻体内的微炎症反应。

关键词: 血液透析, 平衡型氨基酸透析液, 血浆游离氨基酸, 微炎症

Abstract: Objective: To investigate the effects of dialysis with balancing amino acid dialysate in chronic hemodialysis patients. Methods: Twenty-nine chronic hemodialysis patients were dialysis treated with balancing amino acid dialysate for one month. Serum free amino acid, plasma proteins, some markers of inflammation, BUN, Cr, electrolytes were measured before and after treatment. Results: After dialysis with balancing amino acid dialysate for one month, the levels of most kinds free amino acids and the level of total amino acid elevated to normal, and the levels of BUN, SCr and UA elevated. Neither the concentrations of electrolytes, calcium and P , nor the levels of plasma total protein, ALB PreA asn Trf had any significant changes. The serum levels of β2-MG和SCRP decreased significantly, compared with baseline levels (P<0.05). Conclusion: The dialysis with balancing amino acids might prevent the loss of amino acids, improve the metabolic disorder, and inflammatory status in the chronic hemodialysis patients.

Key words: Dialysate containing balanced amino acids, Serum free amino acids, Micro-inflammation

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