目的 研究血清半胱氨酸蛋白酶抑制剂C(Cystatin C，Cys C）与慢性肾脏病(CKD)非透析患者的心功能不全和生化指标的关系。 方法 采用乳胶颗粒增强比浊法检测198例非透析慢性肾脏病患者与25例高血压对照组患者血Cystatin C水平，分析其与心脏彩超结果、既往心血管疾病史和生化指标的关系。 结果 非透析CKD患者Cystatin C水平与对照组相比显著升高，Spearman相关分析显示Cystatin C与LVDd、LVDs、LVMI呈正相关，与EF呈负相关；比肌酐的相关性高。多元回归分析发现心衰是Cystatin C升高的独立危险因子;LVMI、既往心血管事件、GFR、白蛋白是影响血Cystatin C水平的独立危险因素。 结论 在CKD非透析患者中Cys C水平和心功能相关，提示Cys C水平可作为一项评价CKD非透析患者心脏功能的敏感指标

Objective To clarify the association of Cystatin C with cardica dysfunction and biochemical indicator in predialysis patients with chronic kidney disease(CKD). Methods Whole blood concentration of Cystatin C was detected by latex particle enhancement turbidity method in a cohort of 198 non-dialysis CKD patients and 25 hypertensive controls. The relationship of Cystatin C with echocardiographic parametter,biochemical indicator and history of cardiovascular disease in CKD patients was examinned. Result Cystatin C level was significantly higher in CKD patients than that in control subjects. Spearman correlation showed that the Cystatin C level was positively correlated with left ventricular end diastolic dimension(LVDd)、left ventricular end systolic dimension(LVDs)、left ventricular mass index(LVMI); Cystatin C concentration was negatively correlated with ejection fraction， and correlation of Cystatin C and each parameter in cardiac dysfunction washigher than creatinine. multiple regression analysis Revealed that congestive heart failure was an inde- nt danger factor to Cystatin C level.LVMI, history of cardiovascular disease, glomerular filtration rate, albumn were independent determinals of Cystatin C . Conclusion Cystatin C level is significantly correlated with cardiac function and may be a sensitive marker for the evaluation of cardiac function in non-dialysis CKD patients.