关键词: 慢性肾脏病, 非透析, 半胱氨酸蛋白酶抑制剂C, 心脏功能

Abstract: Objective To clarify the association of Cystatin C with cardica dysfunction and biochemical indicator in predialysis patients with chronic kidney disease(CKD). Methods Whole blood concentration of Cystatin C was detected by latex particle enhancement turbidity method in a cohort of 198 non-dialysis CKD patients and 25 hypertensive controls. The relationship of Cystatin C with echocardiographic parametter,biochemical indicator and history of cardiovascular disease in CKD patients was examinned. Result Cystatin C level was significantly higher in CKD patients than that in control subjects. Spearman correlation showed that the Cystatin C level was positively correlated with left ventricular end diastolic dimension(LVDd)、left ventricular end systolic dimension(LVDs)、left ventricular mass index(LVMI); Cystatin C concentration was negatively correlated with ejection fraction， and correlation of Cystatin C and each parameter in cardiac dysfunction washigher than creatinine. multiple regression analysis Revealed that congestive heart failure was an inde- nt danger factor to Cystatin C level.LVMI, history of cardiovascular disease, glomerular filtration rate, albumn were independent determinals of Cystatin C . Conclusion Cystatin C level is significantly correlated with cardiac function and may be a sensitive marker for the evaluation of cardiac function in non-dialysis CKD patients.

Key words: Non-dialysis, Cystatin C, Biochemical index, Cardiac function