血中丙溴磷的测定及包膜活性炭和HA230S树脂的灌流清除百分率

陈雁君 金永久 赵艳霞 曹华伟 张雪梅 闫慧芳

中国血液净化 ›› 2008, Vol. 7 ›› Issue (4) : 192-194.

PDF(591 KB)
PDF(591 KB)
中国血液净化 ›› 2008, Vol. 7 ›› Issue (4) : 192-194.
基础研究

血中丙溴磷的测定及包膜活性炭和HA230S树脂的灌流清除百分率

  • 陈雁君1 金永久1 赵艳霞1 曹华伟2 张雪梅1 闫慧芳3
作者信息 +

Comparison between membrane coated activated charcoal and HA230 absorption resin for the clearance of profenofos in hemoperfusion

  • CHEN Yan-jun1, JIN Yong-jiu1, ZHAO Yan-xia1, CAO Hua-wei2, ZHANG Xue-mei1, YAN Hui-fang3.
Author information +
文章历史 +

摘要

目的 探讨包膜活性炭和HA230树脂对丙溴磷的灌流清除百分率,并比较其清除效果。方法 分别用包膜活性炭和HA230树脂对中毒血样进行灌流吸附,将吸附后血样经乙酸乙酯萃取后,用毛细管气相色谱法检测并计算清除百分率。结果 分析方法的检出限为0.8ng,低、中、高3种浓度的加标回收率为95.1%~101.2%,相对标准偏差为1.11%~10.97%。灌流吸附后血中丙溴磷的清除百分率在包膜活性炭为 78.2%~85.8%,在HA230吸附树脂为84.5%~93.8%。结论 用包膜活性炭和HA230树脂吸附剂进行血液灌流,均能迅速降低血中丙溴磷浓度。

Abstract

Objective To compare the clearance efficiencies of blood profenofos by hemoperfusion with membrane coated activated charcoal and HA230 absorption resin. Method Profenofos standard solutions were mixed with blood samples from healthy subjects, and the profenofos in blood samples was adsorbed by hemoperfusion through a column containing membrane coated activated charcoal or HA230 absorption resin. The remaining profenofos in blood was then extracted by ethylacetate and determined by capillary gas chromatography. Result The lowest limit for blood methamidophos measurement by this method was 0.8ng. The recovery rate to low, middle and high concentrations of blood profenofos was 95.1%~101.2%, with the relative standard deviation of 1.11%~10.97%. By hemoperfusion using membrane coated activated charcoal column and HA230 absorption resin column, the clearance efficiencies were 78.2%~85.8% and 84.5%~93.8%, respectively. Conclusion Blood profenofos can be cleared efficiently and rapidly by hemoperfusion with membrane coated activated charcoal or HA230 absorption resin.

关键词

血液灌流 / 丙溴磷 / 包膜活性炭 / HA230树脂 / 气相色谱法

Key words

Gas chromatography / Hemoperfusion / Membrane coated activated charcoa / HA230 absorption resin

引用本文

导出引用
陈雁君 金永久 赵艳霞 曹华伟 张雪梅 闫慧芳. 血中丙溴磷的测定及包膜活性炭和HA230S树脂的灌流清除百分率[J]. 中国血液净化. 2008, 7(4): 192-194
CHEN Yan-jun;JIN Yong-jiu;ZHAO Yan-xia;CAO Hua-wei;ZHANG Xue-mei;YAN Hui-fang.. Comparison between membrane coated activated charcoal and HA230 absorption resin for the clearance of profenofos in hemoperfusion[J]. Chinese Journal of Blood Purification. 2008, 7(4): 192-194
中图分类号: R459.5   

PDF(591 KB)

Accesses

Citation

Detail

段落导航
相关文章

/