【Abstract】 Objective To observe the effect of high flux hemodialysis (HFHD) using different membrane on lipid metabolism in patients with maintenance hemodialysis. Method Forty patients with maintenance hemodialysis were randomly divided into two groups. Twenty cases were treated with HFHD using F60 dialyser (HFPD group), and 20 cases were treated with low flux hemodialysis (LFPD) using F6 dialyser (LFHD group). Results In HFPD group, serum cholesterol (CHOL), triglyceride (TG), low-density lipoprotein (LDL) decreased, and high-density lipoprotein (HDL) increased after the dialysis for one year. In LFHD group, however, serum TG and LDL increased, HDL decreased, and CHOL remained unchanged. At the beginning of hemodialysis, there were no significant differences in serum CHOL, TG, HDL, LDL and albumin (ALB) between the 2 groups (P＞0.05). In LFHD group, serum CHOL, TG and LDL increased and HDL decreased (P = 0.041) after the dialysis for one year, as compared with those before the dialysis. In contrast in HFPD group, serum CHOL, TG and LDL decreased (P = 0.035, 0.037 and 0.045, respectively) and serum HDL increased (P = 0.035) after the dialysis for one year, as compared with those before the dialysis. When comparisons of serum lipids were made between the 2 groups after the dialysis for one year, serum CHOL (P = 0.005), TG (P = 0.007) and LDL (P = 0.045) were lower, and serum HDL (P = 0.008) and serum ALB (P = 0.038) were higher in HFPD group than in LFPD group. Conclusion HFPD is effective in improving lipid metabolism in hemodialysis patients.