【摘要】目的 了解维生素C透析液对维持性血液透析患者继发性甲状旁腺功能亢进的影响。方法 选择在郑州大学第一附属医院血液净化中心长期透析的患者82例，随机分成两组，分别使用常规透析液(A组40例)和含维生素C透析液(B组42例)进行血液透析，周期为3个月，试验开始前及3个月后分别于透析前抽血化验血清全段甲状旁腺素(intact parathyroid hormone,iPTH)、钙、磷、钙磷乘积、碱性磷酸酶(alkaline phosphatase,ALP)、维生素C水平。结果 A组试验3个月后血清iPTH、ALP轻度升高，钙、磷、钙磷乘积无明显变化，差异无统计学意义(P＞0.05)，维生素 C降低，差异有统计学意义(t=-2.35，P＜0.05)；B组试验3个月后血清iPTH、ALP明显降低，差异有统计学意义(P＜0.05)，钙、磷、钙磷乘积无明显变化，维生素C轻度升高，差异无统计学意义(t=0.14，P＞0.05)。结论 常规透析使大量维生素C丢失；维生素C可以降低血清iPTH、ALP,预防继发性甲状旁腺功能亢进。

【Abstract】 Objective Comprehend the action of vitC-containing dialysate on secondary hyperparathyroidism of maintenance hemodialysis Patients. Methods Eighty-two stable maintenance hemodialysis patients were enrolled in the research, fell into two groups randomly. Then we used routine dialysate and vitC-containing dialysate respectively to do hemodialysis,the Period was three months. We examine the contents of iPTH、Ca、P、CaX、ALP 、VitC pre-and post-treatment before hemodialysis.Results The plasma level of iPTH、ALP rose slightly,Ca、P、CaX had no obviously change,VitC descended after hemodialysis with routine dialysate,the difference was statistically significant;but the level of plasma iPTH、ALP were significantly lower than before, the difference was statistically significant, Ca 、P、CaX had no obviously change,VitC rose slightly after hemodialysis with vitC-containing dialysate.Conclusions A lot of vitC can be lost during the hemodialysis with routine dialysate; VitC can reduce the plasma level of iPTH、ALP and prevent the secondary hyperparathyroidism.