中国血液净化

›› 2012, Vol. 11 ›› Issue (11): 0-0.

• 专题 •    下一篇

腹膜透析对尿毒症患者C反应蛋白的影响及临床意义 II

高小夏   

  1. 江苏省常州市第一人民医院
  • 收稿日期:2012-08-02 修回日期:2012-08-26 出版日期:2012-11-12 发布日期:2012-11-12
  • 通讯作者: 高小夏 E-mail:18912313509@189.cn

Peritoneal dialysis in uremic patients on C-reactive protein levels and its clinical significance II

  • Received:2012-08-02 Revised:2012-08-26 Online:2012-11-12 Published:2012-11-12

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摘要： 目的 探讨腹膜透析对尿毒症患者C反应蛋白的影响及炎症反应与营养不良、贫血及心脑血管疾病的关系。方法 检测健康对照者、尿毒症非透析患者和持续性非卧床腹膜透析（CAPD）患者C反应蛋白（CRP），血清白蛋白（Alb），血红蛋白（Hb），血肌酐（Scr）。并根据CAPD患者CRP水平将其分为正常组（CRP<10mg/L）,异常组（CRP>10mg/L）。结果 尿毒症非透析组和CAPD组CRP水平均高于对照组（P<0.001）,CAPD组CRP水平高于尿毒症非透析组（P<0.01）。CAPD患者CRP水平与Alb，Hb成负相关（P<0.01），CAPD患者CRP水平升高组的心脑血管疾病发生率高于CRP正常组(P< 0.05)。结论 CAPD患者存在CRP水平升高的炎症反应，且高于尿毒症非透析患者，而炎症反应在CAPD患者营养不良和贫血中起着一定的作用，且CAPD患者心脑血管疾病与慢性炎症状态相关。

关键词: 尿毒症 , 腹膜透析 , C反应蛋白 , 营养不良 , 贫血 , 心脑血管疾病 , Uremia, peritoneal dialysis, C-reactive protein, malnutrition, anemia, cardiovascular and cerebrovascular disease

Abstract: Objective To discuss the effect of peritoneal dialysis to C-reactive protein (CRP) of uraemic patients and the relation between inflammation and malnutrition, anemia and cardio-cerebrovascular diseases. Method Detection of C-reaction protein (CRP), serum albumin (Alb), hemoglobin (Hb)，serum creatinine（Scr）of healthy control subjects, non-dialysis uraemic patients and continuous ambulatory peritoneal dialysis (CAPD) patients, and then divide them into normal group (CRP<10mg/L) and abnormal group (CRP>10mg/L) according to the CRP level of CAPD patients. Results The CRP level of both non-dialysis uraemic group and CAPD group are higher than that of healthy control group (P<0.001) while the CRP level of CAPD group is higher than non-dialysis uraemic group（P<0.01）.The CRP level of CAPD patients is negatively associated with Alb and Hb (P<0.01),The probability to have cardio-cerebrovascular disease of elevated CRP level group is higher than normal group (P<0.05). Conclusions CAPD patients have inflammation with a rising CRP level, and this probability is higher than that of non-dialysis uraemic patients. Inflammation plays a role in malnutrition and anemia of CAPD patients, and it also has something to do with cardio-cerebrovascular disease of CAPD patients.

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