长期留置的中心静脉导管（TCC）作为一种重要的血管通路，目前多用于无法建立动静脉内瘘或等待瘘管成熟的维持性血液透析患者，而血栓和纤维鞘形成是导管使用中造成导管功能不良的主要并发症，故导管血栓栓塞预防极为重要。华法林作为一种最古老的抗凝药物，临床上多用于防治血栓栓塞性疾病，如治疗血栓栓塞性静脉炎、肺栓塞及房颤等。目前已有许多研究证明，只要严密监测国际标准化比值（INR），华法林可安全有效预防TCC的血栓和纤维鞘形成，延长导管使用寿命。本文综述华法林在维持血液透析长期留置导管通畅中的作用。

The tunneled cuffed catheter (TCC) as a kind of important vascular access, currently used to the hemodialysis patients who can not establish arteriovenous fistula or wait for its maturity. But thrombus and fiber formation is the major complication caused dysfunction in the use of catheters. Warfarin is a conventional anticoagulant and usually used for preventing thrombus embolism disease, such as treat thromboembolism sex phlebitis, pulmonary embolism and atrial fibrillation. Under the closely monitoring of INR, the effective and safety of warfarin in preventation the thrombosis and malfunction of TCC had been proved for many studies, and it could prolong the life of the catheter. This paper reviews the effect of warfarin keep free of TCC.