患者男，40岁，因全身乏力，食少，恶心，呕吐一周入院。入院后经检查诊断为慢性肾衰竭，CKD5期，给予血液透析治疗。首次行无肝素法透析，无不良反应发生，后来使用肝素抗凝法血液透析，均发生头痛，难以忍受，透后2小时头痛消失，2月后因并发上消化道出血而使用无肝素法透析，头痛消失，当再次使用肝素抗凝后，头痛再次出现，从而考虑头痛与使用肝素钠有关，此后，一直使用无肝素法血液透析维持生命至今

A male patient, aged 40 was admitted for malaise, less appetite and nausea for one week. He was diagnosed with Chronic Renal Failure, CKD stage 5 through examination after admission and hemodialysis treatment was applied. The no-heparin dialysis method was used for the first time with no adverse reactions occurring. Later the heparin anticoagulation hemodialysis was uesd and he had excruciating headaches which disappeared after two hours of hemodialysis end. After two monthes the no-heparin method of dialysis was applied again due to upper gastrointestinal bleeding and the headache disappeared. But the headache reoccurred when we used heparin again.So we conclude that the headache was related to heparin sodium. Therefore no-heparin hemodialysis has been used to sustain the patient s life so far.