高容量血液滤过是在连续性肾脏替代治疗的基础上发展起来的一项血液净化技术，其作为一种高效的非特异性血液净化方法越来越受到学者和临床医生的重视。诸多临床和实验研究显示，与传统连续性静脉-静脉血液滤过相比，能更好的清除炎性介质，改善血流动力学，减少血管活性药物的使用剂量，调节免疫紊乱，提高生存率。本文就高容量血液滤过的概念、作用机制、临床实验研究等现状作一阐述。

High-volume hemofiltration is a kind of blood purification technology that developed on the basis of continuous renal replacement therapy.As a highly efficient nonspecific blood purification method HVHF has attracted more and more scholars and clinicians.Many clinical and experimental research demonstrate that, compared with the traditional continuous veno - venous hemofiltration , HVHF can better remove inflammatory medium, improve blood flow dynamics, reduce vascular active drug dosage, regulate immune disorders, and improve the survival rate. high volume hemofiltration concept, mechanism of action, clinical experiment research will be stated in this paper.