摘要　目的　调查维持性血液透析（MHD）患者牙周炎情况，观察牙周非手术治疗对MHD伴牙周炎患者牙周状况、超敏C反应蛋白（hs-CRP）的影响，并探讨其可能的影响机制。方法　选择MHD患者85名，健康对照组85名。记录一般情况，测取血清hs-CRP及牙周检查。对患者的牙周病指数（PDI）与hs-CRP进行相关性分析。将中、重度牙周炎患者40例，实施牙周非手术治疗，进行基线及治疗后1、3个月的牙周检查并采集血清hs-CRP；采用酶联免疫吸附法测定血清hs-CRP。结果　MHD患者牙周病患病率83.5%、软垢指数（DI）2.1（1.2）、牙石指数（CI） 1.5（0.8）、PDI 3.9（1.9）均明显高于健康对照组 (P＜0.05)。中、重度牙周病组中患者hsCRP水平16.0±6.9mmol/L高于牙周健康和轻度牙周病组11.1±7.4mmol/L (P＜0.05)。实施牙周非手术治疗后MHD患者的牙周临床指标、和hs-CRP水平均明显降低(P＜0.05)。结论　牙周非手术治疗可改善局部炎症状态，减轻MHD伴牙周炎患者全身微炎症状态，有利于透析炎症相关并发症预防和治疗。

Abstract Objective To investigate the maintenance hemodialysis (MHD) patients with chronic periodontal disease . This intervention study was designed to evaluate the effects of non-surgical periodontal therapy on the clinical response and systemic status of MHD patients. and to explore its possible mechanism of influence. Methods Choosing 85 patients with MHD，and other 85 adults from healthy controls group. Record the general conditiongs, have the correlation analysis on periodontal disease index(PDI) and hs-CRP of the patients with MHD. The 40 patients with moderate or severe chronic periodontal disease were treated with non surgical periodontal therapy. The patients were treated with baseline and 1 and 3 months after treatment. The serum hs-CRP was measured by enzyme-linked immunosorbent assay. Results The MHD patients with periodontal disease prevalence rate was 83.5%, debris index (DI) 2.1 (1.2), calculus index (CI) 1.5 (0.8), PDI 3.9 (1.9) were higher than those of healthy control group (P < 0.05). In moderate and severe periodontal disease group, the level of hs-CRP 16 + 6.9mmol/L was higher than that of periodontal health and mild periodontal disease group 11.1 + 7.4mmol/L (P < 0.05). Periodontal clinical parameters and hs-CRP levels were significantly lower in patients with MHD after non-surgical periodontal therapy (P < 0.05). Conclusions Non-surgical periodontal therapy could decrease the local and systemic inflammatory state of MHD patients with chronic periodontal disease, which is beneficial to prevent and treat micro-inflammation of dialysis.