中国血液净化 ›› 2023, Vol. 22 ›› Issue (05): 381-383.doi: 10.3969/j.issn.1671-4091.2023.05.014

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高尿酸血症患者肾脏尿酸排泄能力检测方法

刘 悦  王 悦   

  1. 100191 北京,1北京大学第三医院肾内科
  • 收稿日期:2023-03-30 修回日期:2023-04-10 出版日期:2023-05-12 发布日期:2023-05-12
  • 通讯作者: 王悦 E-mail:bjwangyue@sina.com

Measurement method of renal uric acid excretion ability in patients with hyperuricemia 

LIU Yue, WANG Yue   

  1. Department of Nephrology, Peking University Third Hospital, Beijing 100191, China
  • Received:2023-03-30 Revised:2023-04-10 Online:2023-05-12 Published:2023-05-12
  • Contact: 100191 北京,1北京大学第三医院肾内科 E-mail:bjwangyue@sina.com

摘要: 高尿酸血症患者约90%存在肾脏尿酸排泄能力降低,国内外指南或共识推荐或建议用24小时尿酸排泄分数和/或24小时尿酸排泄量评估肾脏尿酸排泄水平、指导临床分型及用药选择。24小时尿液收集耗时较长,存储和保管条件不一,容易污染和遗漏,影响结果及时性和准确性。研究发现晨尿尿酸排泄分数可以简便、高效以及较好地代替24小时尿尿酸排泄分数评估高尿酸血症患者肾脏尿酸排泄能力,及时指导临床分型和用药。

关键词: 高尿酸血症, 肾脏尿酸排泄不良, 尿酸排泄分数, 24小时尿, 晨尿

Abstract: About 90% of the hyperuricemia patients are found to have renal dysfunction of uric acid excretion. Guidelines and consensus from China and foreign countries have recommend that the 24-hour uric acid excretion fraction and/or 24-hour uric acid excretion can be used for assay of renal uric acid excretion ability, clinical classification and drug selection. However, collection of a 24-hour urine sample takes a long time, and the result may not be accurate due to the possible contamination and incomplete sampling during collection and limited urine storage condition. Previous studies have found that uric acid excretion fraction in random urine sample, especially in morning urine sample, is a simple and efficient method, which may replace the 24-hour uric acid excretion method to evaluate renal uric acid excretion function and to guide clinical classification and treatment in hyperuricemia patients.

Key words: Hyperuricemia, Renal uric acid excretion, Uric acid excretion fraction, 24-hour urine, Morning urine

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