中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (02): 142-145.doi: 10.3969/j.issn.1671-4091.2026.02.012

• 综述 • 上一篇    下一篇

血液净化技术在器官捐献供体维护中的作用和进展

刘金泉   赵圣宝   张良灏   冯 帅   许传屾   

  1. 266000 青岛，1青岛大学附属医院器官移植中心
  • 收稿日期:2025-07-14 修回日期:2025-10-20 出版日期:2026-02-12 发布日期:2026-02-02
  • 通讯作者: 许传屾 E-mail:xcs774279@163.com

The role and advances of blood purification technology in donor maintenance for organ transplantation

LIU Jin-quan, ZHAO Sheng-bao, ZHANG Liang-hao, FENG Shuai, XU Chuan-shen   

  1. Center of OrganTransplant, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2025-07-14 Revised:2025-10-20 Online:2026-02-12 Published:2026-02-02
  • Contact: 266000 青岛，1青岛大学附属医院器官移植中心 E-mail:xcs774279@163.com

摘要： 【摘要】器官捐献是终末期器官衰竭患者的根本救治途径，其成功高度依赖供体维护质量。重型颅脑损伤(severe traumatic brain injury,sTBI)作为主要供体来源，常合并严重内环境紊乱、血流动力学崩溃及多器官功能障碍(multiple organ dysfunction syndrome,MODS)。血液净化(blood purification,BP)技术是危重症救治的重要手段，其中连续性血液净化(continuous blood purification,CBP)通过清除炎性介质、稳定内环境与血流动力学、提供肾脏支持，已成为供体维护的核心干预措施。本文系
统综述CBP在供体维护中的核心价值：包括调控内环境(如纠正高钠血症)、维持循环稳定、实施肾脏替代治疗、清除炎性介质与毒素；同时聚焦其在靶器官(心、肺、肾)保护及特殊供体(中毒、热射病)救治中的价值 与 证 据。当 前 研 究 虽 证 实 CBP 的 临 床 效 益，但 高 质 量 循 证 医 学 证 据[如 随 机 对 照 试 验(randomizedcontrolled trial,RCT)]仍匮乏，尤其在模式优化、标准化方案及长期预后评估方面存在空白。未来需深化研究以完善策略，提升移植器官存活率。

关键词: 器官捐献, 供体维护, 血液净化

Abstract: 【Abstract】Organ donation serves as the fundamental approach for treatment of the patients with endstage organ failure, and the success rate relies heavily on the quality of donor maintenance. Severe traumatic
brain injury is a primary source of donors, but is often complicated with severe internal environment disturbances, hemodynamic collapse, and multiple organ dysfunction syndrome (MODS). Blood purification technology is an important procedure for critical care. Among these techniques, continuous blood purification
(CBP) has emerged as a key intervention for donor maintenance, by clearing inflammatory mediators, stabilizing internal environment and hemodynamics, and providing renal support. This article systematically reviews the esential value of CBP in donor maintenance, including regulating internal environment (e.g., correcting hypernatremia), maintaining circulatory stability, implementing renal replacement therapy, and removing inflammatory mediators and toxins. This review also provides the values and evidences in protecting target organs (heart, lungs and kidneys) and managing special donors (e.g., those with poisoning or heat stroke). Current studies have confirmed the clinical benefits of CBP. However, high-quality evidence-based medical evidence (such as randomized controlled trial) is insufficient, especially in mode optimization, standardized protocols, and long-term outcome evaluation. Future research is needed to refine the strategies and to improve the survival rate of transplanted organs.

Key words: Organ donation, Donor management, Blood purification

中图分类号: