中国血液净化 ›› 2026, Vol. 25 ›› Issue (02): 146-150.doi: :10.3969/j.issn.1671-4091.2026.02.013

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治疗性血浆置换并联连续性肾脏替代治疗的研究进展与实践

孙献坤   王 芳   李 旭   张 凌   陈志文   

  1. 610041 成都,1四川大学华西医院肾脏内科
  • 收稿日期:2025-07-23 修回日期:2025-12-06 出版日期:2026-02-12 发布日期:2026-02-02
  • 通讯作者: 陈志文 E-mail: kiyuhot@163.com

Research progress and practice of therapeutic plasma exchange in tandem with continuous renal replacement therapy

SUN Xian-kun, WANG Fang, LI Xu, ZHANG Ling, CHEN Zhi-wen   

  1. 1Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2025-07-23 Revised:2025-12-06 Online:2026-02-12 Published:2026-02-02
  • Contact: 610041 成都,1四川大学华西医院肾脏内科 E-mail: kiyuhot@163.com

摘要: 治疗性血浆置换(therapeutic plasma exchange,TPE)已被证实对多种疾病有效,然而,有些疾病可能需要同时进行连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)。TPE并联CRRT技术,可以实现2种体外血液净化同时进行。然而,开展TPE并联CRRT技术的可行性和安全性、治疗效果、应用前景尚不明确。鉴于此,笔者团队查阅文献,介绍TPE形式,梳理TPE并联CRRT形式,总结TPE并联治疗优缺点及笔者单位临床实践经验,便于开展后续并联研究。

关键词: 治疗性血浆置换, 连续性肾脏替代治疗, 并联

Abstract: Therapeutic plasma exchange (TPE) has been proven effective for various diseases, but some conditions may require concurrent continuous renal replacement therapy (CRRT). The TPE-CRRT combination technique enables both forms of extracorporeal blood purification to be performed simultaneously. However, the feasibility, safety, therapeutic efficacy, and application prospects of the TPE-CRRT combination technique remain unclear. In light of this, our team reviewed the literature, introduced the forms of TPE, summarized the forms of TPE combined with CRRT, and outlined advantages and disadvantages of the combined therapy, as well as our clinical experience, to facilitate future research on combined therapy.

Key words: Therapeutic plasma exchange, Continuous renal replacement therapy, Tandem

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