中国血液净化

›› 2005, Vol. 4 ›› Issue (12): 649-651.

• 论著 • 上一篇    下一篇

应用DNA280免疫吸附器治疗系统性红斑狼疮的观察

汤 颖 娄探奇 陈珠江 王 成 刘 迅

  

  1. 510630 广州，中山大学附属第三医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-12-12 发布日期:2005-12-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-12-12 Published:2005-12-12

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摘要： 目的 观察DNA280免疫吸附器治疗系统性红斑狼疮 (systemic lupus erythematosus, SLE) 的效果。 方法 选取30例系统性红斑狼疮患者，运用DNA280免疫吸附器治疗，检测吸附治疗前后抗核抗体(ANA)、抗双链DNA抗体(ds-DNA)、IgA、IgG、IgM的抗体滴度变化、补体C3、C4、血常规、电解质、肾功能、肝功能等指标并行统计学分析。结果 免疫吸附治疗后，患者ANA、ds-DNA抗体滴度明显减少(P＜0.05)；血常规及其他各项生化指标无明显改变，无肝肾功能损害(P＞0.05)，临床症状有不同程度的缓解。结论 DNA280免疫吸附器对系统性红斑狼疮治疗有效，能减少ANA、ds-DNA滴度水平，并且安全、无明显副反应。

关键词: DNA280免疫吸附器, 免疫吸附, 系统性红斑狼疮, 抗核抗体(ANA), 抗双链DNA抗体(ds-DNA)

Abstract: Objective To observe clinical effect of DNA280 immunoadsorbent on systemic lupus erythematosus (SLE) patients. Methods Strictly according to the standard of inclusion and exclusion, selecting 30 patients with SLE patients to accept immunoadsorption therapy and detect the titres of ANA and ds-DNA in pre-treatment and after-treatment, Morever, the concentrations of IgA、IgG、IgM antibody 、C3、C4 and the change of blood routine 、electrolyte 、renal function、hepatic function，then analyzed results by statistics, P＜0.05 was considered as significant difference. Results the titres of ANA and ds-DNA decreased after treatment which was significant difference compared with pretreatment(P＜0.05)；the parameters of blood routine, biochemical indicator remained static without obvious liver and nephron function loss.The clinical symptoms were improved. Conclusion DNA280 immunoadsorbent has definitely better therapeutic effect which can exclusively decrease the levels of ANA、ds-DNA. The immunoadsorption is safe and no obvious side effects.

Key words: Immunoadsorption, Systemic lupus Erythematosus, Antinuclear antibody(ANA), Anti-DNA antibody(ds-DNA)

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