中国血液净化

›› 2004, Vol. 3 ›› Issue (3): 141-143.

• 论著 • 上一篇    下一篇

透析膜的生物相容性对血清细胞因子的影响

陈昕丽   

  1. 063000 唐山，河北省华北煤炭医学院附属开滦医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-03-12 发布日期:2004-03-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-03-12 Published:2004-03-12

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摘要： 目的 探讨透析膜的生物相容性对血液透析患者血清细胞因子水平的影响。 方法 用ELISA 法检测26例不同透析膜透析患者的透析前、后血清IL-12、细胞免疫调节因子IFN-γ、体液免疫调节因子IL-4的水平。 结果 铜仿膜(Cup)透析后与透析前相比血清 IL-12 水平增高，IFN-γ 水平降低， P < 0.05；聚砜膜 (PS)、血仿膜(HE)透析对血清 IL-12和IFN-γ水平无明显影响。三种透析膜透析后对血清IL-4水平无明显影响，但各组相比以铜仿膜透析组血清IL-4水平最低， P<0.01。 结论 透析膜的生物相容性影响透析患者血清细胞因子水平。提示非生物相容性透析膜可能损害透析患者免疫功能。

关键词: 血液透析, 透析膜, 生物相容性, 细胞因子

Abstract:

Objective To investigate the influence of hemodialysis membrane's biocom-patibility on serum cytokines in hemodialysis(HD) patients. Methods The serum levels of IL-12、IFN-γ、IL-4 in 26 patients dialyzed with different membranes were measured by ELISA before and after a dialysis session. Results After dialyzed with Cuprophan(Cup) membrane, the serum IL-12 levels of these patients were higher and IFN-γ levels were lower than the levels before dialyzed with Cup, P<0.05, while Polysulfone(PS) membranes and Hemophan (HE) membranes had little influence on serum IL-12 and IFN-γ levels of the patients. After HD, the three different membranes had no effects on patients' serum IL-4 levels, but the IL-4 levels of patients dialyzed with Cup membrane were lower than other groups before and after HD, P<0.01. Conclusion Hemodialysis membrane's biocompatibility has influence on levels of the serum cytokines in HD patients. This suggests that hemodi-alysis membrane's bioincompatibility may injure HD patients' immune system.

Key words: Dialysis membrane, Biocompatibility, Cytokines

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