中国血液净化

›› 2004, Vol. 3 ›› Issue (4): 205-206.

• 基础研究 • 上一篇    下一篇

带蒂大网膜包肾术对肾小球硬化大鼠肾皮质IV型胶原基因表达的影响

董兴刚 安增梅 杨海春 周江华 殷祥雷 顾建新   

  1. 200011 上海，上海市第二人民医院肾内科(董兴刚，安增梅)200040 上海，复旦大学华山医院肾内科(杨海春，周江华)200032 上海，复旦大学医学院基因研究中心(殷祥雷，顾建新)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-04-12 发布日期:2004-04-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-04-12 Published:2004-04-12

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摘要：

目的 探讨带蒂大网膜包肾术（ POT）对肾小球硬化大鼠肾皮质IV型胶原基因表达的影响。方法 采用单侧肾切除加二次注射阿霉素制备肾小球硬化大鼠模型,观察带蒂大网膜包肾术对肾小球硬化大鼠肾皮质IV型胶原基因表达的影响。结果 带蒂大网膜包肾术使肾小球硬化大鼠肾皮质IV型胶原基因表达明显上调, 肾小球硬化减轻。结论 带蒂大网膜包肾术下调肾小球硬化大鼠肾皮质IV型胶原基因表达，延缓肾小球硬化

关键词: 带蒂大网膜包肾术, 肾小球硬化, IV型胶原

Abstract:

Objective To investigate the effect of pedicled omental transposition on type IV collagen mRNA in glomerulosclerosis rats. Methods Three groups of 24 uistar rats were studied: 9 as normal control, 6 as glomerulosclerosis group induced by unilateral nephrectomy and injection of adriamycin, and 9 glomerulosclerosis rats treated with pedicled omental transposition surgery as pedicted omental transposition group. Results Pedicled omental trans-position group could not only decrease the accumulation of extracellular matrix( P<0.05), but also the expression of type IV collagen mRNA (P<0.05). Conclusion Pedicled omental transposition may decrease the accumulation of extracellular matrix and attenuate glomerulosclerosis by down-regulating type IV collagen mRNA expression.

Key words: Glomerulosclerosis, Type IV collagen mRNA

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