中国血液净化

›› 2004, Vol. 3 ›› Issue (6): 313-315.

• 论著 • 上一篇    下一篇

维生素E修饰的透析膜对血液透析患者血脂的影响

赵轶雯 王质刚   

  1. 100050 北京，首都医科大学附属天坛 医院肾内科（赵轶雯）100050 北京，首都医科大学附属友谊医院肾内科（王质刚）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-06-12 发布日期:2004-06-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-06-12 Published:2004-06-12

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摘要：

目的 观察 VitE修饰的透析膜对血液透析患者血脂的影响。方法 40名稳定血液透析患者随 机分为2组。A组（n=20）用 VitE修 饰的透析膜透析；B组(n=20)用纤维素透析膜透析,观察4周。分别于第1次和第13次透析前抽 血，测定血浆和红细胞中丙二醛（MDA）、VitE及血浆中的甘油三酯(TG)、总胆固醇(TCH )、低密度脂蛋白（LDL）、高密度脂蛋白(HDL)、脂蛋白A［Lp(a)］、载脂蛋白B（ApoB ）、载脂蛋白A1（ApoA1）浓度。结果 A组实验结束比实验前血浆VitE（P=0.003）和红细 胞中 VitE（P=0.032）明显升高，血浆MDA ( P=0.043)和 红细胞内 MDA (P=0.033)明显下降。TC、TG、LDL、HDL无明显变化，但Lp(a) ( P=0.049)、 ApoB (P=0.040)明显下降， ApoA1 (P=0.027)较前明显升高。B组实验前后观察指标无明显变化。结论 使用VitE修饰的透析膜透析有抗氧化作用，改善脂质代谢，有助于防止动脉粥样硬化。

关键词: 血液透析, 氧化应激, 维生素E修饰透析膜, 血脂

Abstract:

Objective To evaluate the effects of vitamin E-modified dialysis membrane on lipid for patients on haemodialysis. Methods In our study, 40 patients on maintenance haemodi alysis were divided into two groups randomly. Patient s in group A (n=20) received haemodialysis with VitE-modified membrane; patients in group B(n=20) received haemodialysis merely with conventional dialyzers for a period of four weeks. Blood samples were collected prior to the first and thir teenth dialysis sessions to determine the concentrations of malonylaldehyde (MDA ) and vitamin E in plasma and red blood cells (RBC), and of triglyceride (TG), t otal cholesterol (TCH), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein A［Lp(a)］, apolipoprotein B (ApoB) and apolipoprotein A1 (A poA1) in plasma. Results In group A, as compared with the parameters at t he initiation of the study, it was demonstrated that there was significant incre ase in Vit E in both plasma (P=0.003) and RBC (P=0.032), and obvious decline in MDA in both plasma (P=0.043) and RBC ( P=0.033); it was also demonstrated that there was no marke d changes in TC, TG, LDL and HDL, but obvious decline in Lp(a)(P=0.049) and ApoB (P=0.040) and significant increase in ApoA1(P=0.027). In Group B, there was, however, no significant changes d etected at all in all the relevant parameters upon conclusion of the study. Conclusion Our study demon-strates that Vit E-modified membrane may have anti-oxidant effects on haemodialysis patients, and exhibit an advanta ge in improving lipoprotein metabolism, conducive to the prevention of atheroscl erosis. 

Key words: Oxidative stress, VitE-modifi ed dialysis membrane, Lipid

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