中国血液净化

›› 2003, Vol. 2 ›› Issue (10): 554-557.

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慢性肾衰竭维持性血液透析合并丙型肝炎患者血清心肌肌钙蛋白的变化

戎其飞 赵卫红 王笑云 苏恩本 毛慧娟 杨志健   

  1. 210029 南京，南京医科大学第一附属医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-10-19 发布日期:2003-10-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-10-19 Published:2003-10-19

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摘要： 目的 观察慢性肾衰竭（CRF）维持性血液透析合并丙型肝炎患者血清心肌肌钙蛋白(cTnI)的 异常变化。方法 应用双抗夹心酶联免疫吸附法（ELISA）检测115例维持性血液透析患者分为丙型肝炎阳性组70例和阴性组45例及64例正常人的血清cTnI。结果 慢性肾衰竭组血清 cTnI 阳性率为 17.4%，其中丙型肝炎阳性组为20%，丙型肝炎阴性组为13.3%，丙型肝炎阳性组cTnI水平显著高于丙型肝炎阴性组 (P<0.01)。结论 慢性肾衰竭血液透析患者的心肌损伤明显高于正常人群，合并丙型肝炎可加重慢性肾衰竭血液透析患者的心肌损伤，提示丙型病毒能引起心肌损伤。

关键词: 慢性肾衰竭, 丙型病毒性肝炎, 肌钙蛋白 I, 心肌损伤

Abstract: Objective To explore change of serum troponin I（cTnI） in hemodialysis patients with hepatitis C. Methods By enzyme-linked immunosorbent assay(ELISA),the levels of serum cTnI were measured in 64 healthy persons and 115 patients with chronic renal failure（CRF）undergoing hemodialysis,which were divided into 70 patients with HCV antibody positive and 45 patients with HCV antibody negative. Results The levels of serum troponin I in 17.4%（20/115）CRF patients was higher than normal value. The positive rates were 13.3%（6/45）and 20%（14/70）in HCV antibody negative group and HCV antibody positive group respectively.The levels of serum cTnI in HCV antibody positive group were significantly higher than those of negative group( P＜0.01). Conclusions Myocardium impairments were prevalent in hemodialysis patients, and those with hepatitis C were stressed myocardium impairments in hemodialysis patients. It suggests that the hepatitis C virus may cause myocardium impairments. 

Key words: Hepatitis C, Troponin I, Myocardium impairments 