中国血液净化

›› 2008, Vol. 7 ›› Issue (12): 641-643.

• 基础研究 • 上一篇    下一篇

醋酸纤维/聚乙烯基亚胺膜去除血清胆红素同时对肝病相关因子影响的研究

李蕾蕾 段志军 鞠佳   

  1. 连医科大学附属第一医院消化内科；大连理工大学膜科学与技术研究中心
  • 收稿日期:2008-08-14 修回日期:1900-01-01 出版日期:2008-12-12 发布日期:2008-12-12
  • 通讯作者: 段志军

Experimental study on CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin

LI Lei-lei, DUAN Zhi-jun, JU Jia   

  1. 1Gastroenterology Dept., First Affiliated Hospital of Dalian Medical University, Dalian 116011; 2:Membrane Science and Technology Center, Dalian University of Technology, Dalian 116011,China
  • Received:2008-08-14 Revised:1900-01-01 Online:2008-12-12 Published:2008-12-12

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摘要： 目的 探讨CA/PEI膜在吸附血清胆红素同时对慢性肝病患者部分细胞因子、免疫球蛋白、补体的影响。方法 应用CA/PEI膜吸附30例黄疸患者血清，ELISA法测定吸附前后IL-6、IL-10、TNF-α和TGF-β1含量，免疫散射比浊法测定IgA、IgM、IgG，C3和 C4含量。结果 吸附后IL-6、TNF-α和TGF-β1下降(P＜0.05)，IL-10无明显变化；免疫球蛋白和补体亦无变化。结论：CA/PEI膜在去黄同时可对肝病进展相关的一些血液成分有不同影响。

关键词: 亲和膜, 细胞因子, 免疫指标

Abstract: Objective To study the effect of CA/PEI membrane on cytokines, immunoglubin and complements along with bilirubin clearance in chronic liver diseases. Methods We used CA/PEI membrane to adsorb jaundice sera from 30 cases for 2 hours. Serum IL-6, IL-10, TNF-α and TGF-β1 were measured by ELISA before and after the adsorption. IgA, IgM, IgG, C3 and C4 were detected by immune scatter turbidimetry. Results After the adsorption, serum IL-6, TNF-α and TGF-β1 decreased (P＜0.05), and IL-10, immunoglobulin and complements remained unchanged. Conclusion CA/PEI membrane may affect several cytokines relating to the progress of liver diseases in company with bilirubin clearance.

Key words: Cytokines, Immune index

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