醋酸纤维/聚乙烯基亚胺膜去除血清胆红素同时对肝病相关因子影响的研究

李蕾蕾; 段志军; 鞠佳

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中国血液净化 ›› 2008, Vol. 7 ›› Issue (12) : 641-643.

基础研究

醋酸纤维/聚乙烯基亚胺膜去除血清胆红素同时对肝病相关因子影响的研究

李蕾蕾段志军鞠佳

作者信息 +

Experimental study on CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin

LI Lei-lei, DUAN Zhi-jun, JU Jia

Author information +

文章历史 +

摘要

目的探讨CA/PEI膜在吸附血清胆红素同时对慢性肝病患者部分细胞因子、免疫球蛋白、补体的影响。方法应用CA/PEI膜吸附30例黄疸患者血清，ELISA法测定吸附前后IL-6、IL-10、TNF-α和TGF-β1含量，免疫散射比浊法测定IgA、IgM、IgG，C3和 C4含量。结果吸附后IL-6、TNF-α和TGF-β1下降(P＜0.05)，IL-10无明显变化；免疫球蛋白和补体亦无变化。结论：CA/PEI膜在去黄同时可对肝病进展相关的一些血液成分有不同影响。

Abstract

Objective To study the effect of CA/PEI membrane on cytokines, immunoglubin and complements along with bilirubin clearance in chronic liver diseases. Methods We used CA/PEI membrane to adsorb jaundice sera from 30 cases for 2 hours. Serum IL-6, IL-10, TNF-α and TGF-β1 were measured by ELISA before and after the adsorption. IgA, IgM, IgG, C3 and C4 were detected by immune scatter turbidimetry. Results After the adsorption, serum IL-6, TNF-α and TGF-β1 decreased (P＜0.05), and IL-10, immunoglobulin and complements remained unchanged. Conclusion CA/PEI membrane may affect several cytokines relating to the progress of liver diseases in company with bilirubin clearance.

导出引用

李蕾蕾段志军鞠佳. 醋酸纤维/聚乙烯基亚胺膜去除血清胆红素同时对肝病相关因子影响的研究[J]. 中国血液净化. 2008, 7(12): 641-643

LI Lei-lei;DUAN Zhi-jun;JU Jia. Experimental study on CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin[J]. Chinese Journal of Blood Purification. 2008, 7(12): 641-643

中图分类号： R318.14