中国血液净化

›› 2011, Vol. 10 ›› Issue (3): 133-135.doi: 10.3969/j.issn.1671-4091.2011.03.00

• 临床研究 • 上一篇    下一篇

高通量血液透析对维持性血液透析患者微炎症状态的影响

徐丰博 孙 懿 刘惠兰   

  1. 首都医科大学附属复兴医院肾内科
  • 收稿日期:2010-07-08 修回日期:1900-01-01 出版日期:2011-03-12 发布日期:2011-03-12
  • 通讯作者: 孙懿

Changes of microinflammatory state in hemodialysis patients using high-flux membrane dialyzer

XU Feng-bo, SUN Yi, LIU Hui-lan   

  1. Department of Nephrology, Fuxing Hospital, Capital University of Medical Science, Beijing 100038, China
  • Received:2010-07-08 Revised:1900-01-01 Online:2011-03-12 Published:2011-03-12

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摘要： 目的 前瞻性研究高通量血液透析对患者微炎症状况的影响。 方法 前瞻性、自身对照研究。30例维持性常规低通量血液透析患者转换为高通量血液透析12个月。治疗0个月(治疗前)、6个月、12个月分别测定血中高敏C反应蛋白、白细胞介素1和白细胞介素6。 结果 转换为高通量透析12个月后，血清白细胞介素6水平明显下降(P＜0.05)，高敏感C反应蛋白和白细胞介素1水平较前无明显变化。 结论 长时间高通量血液透析不会加剧透析患者体内微炎症状态，而且可能对微炎症状态有一定改善作用。

关键词: 高通量血液透析, 高敏C反应蛋白, 白细胞介素1, 白细胞介素6

Abstract: Objective This is a prospective and self-controlled study designed to detect whether the microinflammatory state improves in hemodialysis patients using high-flux dialysis. Methods Thirty patients on maintenance low-flux hemodialysis were included in this study. They were then switched the dialyzer from low-flux dialyzer to high-flux F60 or FX60 dialyzer without changes of dialysis prescription. Ultrapure dialysate was used in the dialysis. Serum high sensitivity C-reactive protein (hCRP), interleukin-1 (IL-1), interleukin-6 (IL-6) and albumin were determined after the switch for 0, 6 and 12 months. Results After the switch from low-flux hemodialysis to high-flux hemodialysis for 12 months, serum hCRP and IL-1 remained unchanged. Serum IL-6 was 39.97±41.03ng/L, 36.81±37.09ng/L and 15.17±1.54ng/L (P<0.05) after the switch for 0, 6 and 12 months, respectively. Conclusions Switch from low-flux hemodialysis to high-flux hemodialysis may improve the microinflammatory state in maintenance hemodialysis patients.

Key words: High sensitivity C-reactive protein, Interleukin-1, Interleukin-6