【Abstract】 Objective To observe the effect of HB-H-6 resin plasma perfusion in the treatment of severe jaundice. Methods Sixty-one patients (male 52 and female 9; 44-71 years of age with mean age of 55 years) with severe jaundice were enrolled in this study. They were diagnosed with hepatocellular jaundice caused by acute or chronic liver function failure or severe hepatitis. Patients were treated with HB-H-6 resin plasma perfusion unit. Plasma bilirubin, protein, electrolyte and blood routine examinations were assayed before perfusion and 2 hours after plasma perfusion. Blood pressure, heart rate, respiration and temperature were monitored regularly. Results Perfusion continued for 2 hours. After the perfusion, plasma total bilirubin decreased by 29 %, indirect bilirubin decreased by 26 %, direct bilirubin decreased by 31 % (P＜0.05), plasma protein decreased by 7 %, albumin decreased by 9 %, and globulin decreased by 4 % (P＜0.05), but without significant changes in serum K+, Na+, Ca2+, Mg2+ and Phosphate (P＞0.05). After the perfusion, WBC increased by 2 %, RBC decreased by 1%, and platelet decreased by 6 % (P＞0.05). During the perfusion, heart rate, blood pressure, respiration and body temperature remained stable. Conclusion Plasma perfusion with HB-H-6 resin is an effective and safe approach for the treatment of severe hepatocellular jaundice.