中国血液净化

›› 2008, Vol. 7 ›› Issue (7): 357-360.

• 论著 • 上一篇    下一篇

尿毒症脑病的心理因素分析

邓英辉 贾 强   

  1. 首都医科大学宣武医院肾脏内科
  • 收稿日期:2008-04-02 修回日期:1900-01-01 出版日期:2008-07-12 发布日期:2008-07-12

Analysis of psychological factors in patients with uremic encephalopathy

DENG Ying-hui, JIA Qiang   

  1. Department of Nephrology, Beijing Xuanwu Hospital, Capital University of Medical Science, Beijing 100053, China
  • Received:2008-04-02 Revised:1900-01-01 Online:2008-07-12 Published:2008-07-12

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摘要： 【摘要】目的 探讨心理因素在尿毒症脑病发病过程中的作用。方法 以慢性肾脏病(CKD5期)患者为观察对象进行病例对照研究。采用症状自评量表(SCL-90)、抑郁自评量表(SDS)、焦虑自评量表(SAS)对患者的心理状况进行评估。选择其后发生尿毒症脑病者23名为病例组，未发生尿毒症脑病者23名为对照组。比较抑郁、焦虑等负性情绪表现在两组间的差异，探讨负性情绪在尿毒症脑病发病过程中的作用。结果 病例组SCL-90总分及各症状因子分，SDS和SAS标准分均高于对照组(P＜0.01或P＜0.05）。病例组的SCL-90总分及躯体化、强迫、人际敏感、抑郁、焦虑、恐怖等6项症状因子阳性检出率，SDS评分阳性率和SAS评分阳性率均明显高于对照组(P＜0.01或P＜0.05），OR值3.56～7.39。结论 抑郁、焦虑等负性情绪可能是尿毒症脑病发生的危险因素。

关键词: 尿毒症脑病, 心理因素, 负性情绪

Abstract:

【Abstract】 Objective To evaluate psychological factors in the pathogenesis of uremic encephalopathy. Methods We recruited 23 chronic kidney disease patients with uremic encephalopathy (CKD at 5th stage) as the illness group (group A), and 23 CKD patients without uremic encephalopathy as the control group (group B). Their psychological problems were evaluated by using the symptom checklist 90 (SCL-90), self-rating depression scale (SDS) and self-rating anxiousness scale (SAS) before the presence of uremic encephalopathy. Results The illness group had significant higher scores of SCL-90 in global indices and every symptom scales, SDS and SAS evaluations (P＜0.01 or P＜0.05, as compared with those of the control group). Patients in the illness group had higher positive rates in SCL-90 scores of global indices and symptom scales of somatization, obsession, interpersonal sensitivity, depression, anxiety and phobia, as well as higher scores of SDS and SAS (OR 3.56～7.39; P＜0.01 or P＜0.05, as compared with those of the control group). Conclusion Negative emotional changes such as depression and anxiety may be the risk factors for the presence of uremic encephalopathy in CKD patients

Key words: Psychological factors, Negative emotion

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