中国血液净化

›› 2011, Vol. 10 ›› Issue (7): 361-364.doi: 10.3969/j.issn.1671-4091.2011.07.00

• 临床研究 • 上一篇    下一篇

慢性肾衰竭并发恶性肿瘤46例的临床分析

张 帆 罗 琼 侯 霜 熊子波 熊祖应   

  1. 北京大学深圳医院肾内科
  • 收稿日期:2010-11-25 修回日期:1900-01-01 出版日期:2011-07-12 发布日期:2011-07-12
  • 通讯作者: 熊祖应

Clinical analysis of 46 cancer cases with chronic renal failure in Shenzhen Hospital

ZHANG Fan, LUO Qiong, HOU Shuang, XIONG Zi-bo, XIONG Zu-ying   

  1. Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Received:2010-11-25 Revised:1900-01-01 Online:2011-07-12 Published:2011-07-12

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摘要：

目的 了解慢性肾衰竭(chronic renal failure,CRF)患者恶性肿瘤的发生率及临床特点。 方法 回顾性调查北京大学深圳医院1999年9月至2009年8月住院的CRF并发恶性肿瘤患者，与同期住院的非CRF患者恶性肿瘤发病情况及2006年全国恶性肿瘤发病数据进行比较，分析CRF患者并发恶性肿瘤的流行病学特征、部位分布、发生时间等。 结果 2324例CRF患者中46例并发恶性肿瘤，发生率为2.0%，9例(19.6%)为规律性透析(血液透析或腹膜透析)后发生，35例(72.9%)在CRF后2年内发生。恶性肿瘤的部位主要是泌尿系统和消化系统，并发恶性肿瘤时平均年龄明显高于非CRF恶性肿瘤患者。 结论 CRF患者发生恶性肿瘤风险高于一般人群，应重视老年人、CRF后2年内泌尿系统和消化系统肿瘤筛查。

关键词: 慢性肾衰竭, 恶性肿瘤, 透析, 泌尿系统, 消化系统

Abstract:

Objective To investigate the incidence and clinical characteristics of cancer patients with chronic renal failure (CRF) in Shenzhen. Methods We retrospectively reviewed all hospitalized cancer patients with CRF from Sept. 1999 to Aug. 2009 in our hospital. The epidemic characteristics and cancer sites in CRF patients were compared with those in non-CRF cancer patients and those from National Cancer Survey in 2006. Results In a total 2324 hospitalized CRF patients, cancers were found in 46 cases (2%), of whom 9 (19.6%) were treated with dialysis (hemodialysis or continuous ambulatory peritoneal dialysis), and 35 (72.9%) were detected to have cancer within 2 years after the diagnosis of CRF. Cancers were mainly found in urological or digestive systems. The average age when the cancer was detected in CRF patients was elder than that in non-CRF cancer patients. Conclusions CRF patients are at the higher risk of developing cancers than general population. Cancer screening, especially for cancers in urological and digestive systems, should be conducted in patients of older age and diagnosed with CRF within two years.

Key words: Cancer, Dialysis, Urological system, Digestive system