中国血液净化

›› 2008, Vol. 7 ›› Issue (7): 380-382.

• 基础研究 • 上一篇    下一篇

血液灌流吸附剂对百草枯吸附作用的实验研究

张秀敏 黄立纲 国建琴 孙晓鹏 苏晓辉   

  1. 065000 廊坊,1河北省廊坊市爱尔血液净化器材厂 100016 北京,2清华大学第一附属医院检验科
  • 收稿日期:2008-03-21 修回日期:1900-01-01 出版日期:2008-07-12 发布日期:2008-07-12
  • 通讯作者: 国建琴

Experimental study on adsorption of paraquat by hemoperfusion adsorbents

ZHANG Xiu-min, HUANG Li-gang, GUO Jian-qin, SUN Xiao-peng   

  1. 1Langfang Aier Blood Purification Apparatus Factory, 2The First Affiliated Hospital of Tsinghua University, Langfang 065000, China.
  • Received:2008-03-21 Revised:1900-01-01 Online:2008-07-12 Published:2008-07-12

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摘要： 【摘要】目的 探讨血液灌流吸附剂对百草枯的吸附作用。 方法 采用0.5%百草枯溶液200ml、100ml、50ml及0.01%百草枯溶液200ml进行体外循环吸附2小时，观察百草枯浓度的变化，以计算活性炭及大孔吸附树脂对百草枯的吸附率。结果 百草枯的浓度为0.5%，循环容积为200ml，百草枯含量为1000mg时，活性炭和树脂的吸附率为46%、35%；百草枯的浓度为0.5%，循环容积为100ml，百草枯含量为500mg时，活性炭和树脂的吸附率为65%、47%；百草枯的浓度为0.5%，循环容积为50ml，百草枯含量为250mg时活性炭和树脂的吸附率为88%、57%；百草枯的浓度为0.01%，循环容积为200ml，百草枯含量为20mg时，活性炭和树脂的吸附率为95%、87%。结论 在百草枯浓度较低0.01%、较低含量20 mg时和百草枯浓度较高0.5%、较高含量时，活性炭清除百草枯的作用优于大孔吸附树脂，但无统计学差异，临床上清除百草枯可以选用炭肾或树脂吸附柱进行血液灌流治疗。

关键词: 百草枯, 血液灌流吸附剂, 活性炭, 大孔吸附树脂, 吸附率

Abstract: 【Abstract】 Objective To study the adsorption of paraquat by different hemoperfusion adsorbents. Methods We added 0.5% paraquat solution 200 ml, 100ml, 50ml and 0.01% paraquat solution 200 ml in the extracorporeal circulation system for adsorption for 2 hours, observed the change of paraquat concentration, and calculated the adsorption rate of paraquat by activated carbon and macroporous resin. Results when paraquat concentration was 0.5% and the circulation volume was 200ml, the adsorption rate of parquet by activated carbon and resin was 46% and 35%, respectively. With the decrease of circulation volume, the adsorption rate was increased. When the paraquat concentration was 0.01% and the circulation volume was 200ml，the adsorption rate by activated carbon and macroporous resin was 95% and 87%, respectively. Conclusion At any paraquat concentrations, the adsorption rate of activated carbon is higher than that of macroporous resin but without statistical significance. Clinically, either charcoal kidney or resin adsorption column can be used for the clearance of paraquat by hemoperfusion therapy.

Key words: Hemoperfusion adsorbent, Activated carbon, Macroporous resin, Adsorption rate

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